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dc.contributor.authorPorta, A.en
dc.contributor.authorMarchi, A.en
dc.contributor.authorBari, V.en
dc.contributor.authorDe Maria, B.en
dc.contributor.authorEsler, M.en
dc.contributor.authorLambert, E.en
dc.contributor.authorBaumert, M.en
dc.identifier.citationPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2017; 375(2096):20160290-1-20160290-12en
dc.description.abstractThe study assesses the strength of the causal relation along baroreflex (BR) in humans during an incremental postural challenge soliciting the BR. Both cardiac BR (cBR) and sympathetic BR (sBR) were characterized via BR sequence approaches from spontaneous fluctuations of heart period (HP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and muscle sympathetic nerve activity (MSNA). A model-based transfer entropy method was applied to quantify the strength of the coupling from SAP to HP and from DAP to MSNA. The confounding influences of respiration were accounted for. Twelve young healthy subjects (20–36 years, nine females) were sequentially tilted at 0°, 20°, 30° and 40°. We found that (i) the strength of the causal relation along the cBR increases with tilt table inclination, while that along the sBR is unrelated to it; (ii) the strength of the causal coupling is unrelated to the gain of the relation; (iii) transfer entropy indexes are significantly and positively associated with simplified causality indexes derived from BR sequence analysis. The study proves that causality indexes are complementary to traditional characterization of the BR and suggests that simple markers derived from BR sequence analysis might be fruitfully exploited to estimate causality along the BR. This article is part of the themed issue ‘Mathematical methods in medicine: neuroscience, cardiology and pathology’.en
dc.description.statementofresponsibilityAlberto Porta, Andrea Marchi, Vlasta Bari, Beatrice De Maria, Murray Esler, Elisabeth Lambert, Mathias Baumerten
dc.publisherRoyal Societyen
dc.rights© 2017 The Author(s) Published by the Royal Society. All rights reserved.en
dc.subjectWiener–Granger causality; heart rate variability; muscle sympathetic nerve activity; head-up tilt; autonomic nervous system; cardiovascular controlen
dc.titleAssessing the strength of cardiac and sympathetic baroreflex controls via transfer entropy during orthostatic challengeen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidBaumert, M. [0000-0003-2984-2167]en
Appears in Collections:Medicine publications

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