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Type: Journal article
Title: From KIDSCREEN-10 to CHU9D: creating a unique mapping algorithm for application in economic evaluation
Author: Chen, G.
Stevens, K.
Rowen, D.
Ratcliffe, J.
Citation: Health and Quality of Life Outcomes, 2014; 12(1):134-1-134-11
Publisher: BioMed Central
Issue Date: 2014
ISSN: 1477-7525
Statement of
Gang Chen, Katherine Stevens, Donna Rowen and Julie Ratcliffe
Abstract: BACKGROUND: The KIDSCREEN-10 index and the Child Health Utility 9D (CHU9D) are two recently developed generic instruments for the measurement of health-related quality of life in children and adolescents. Whilst the CHU9D is a preference based instrument developed specifically for application in cost-utility analyses, the KIDSCREEN-10 is not currently suitable for application in this context. This paper provides an algorithm for mapping the KIDSCREEN-10 index onto the CHU9D utility scores. METHODS: A sample of 590 Australian adolescents (aged 11-17) completed both the KIDSCREEN-10 and the CHU9D. Several econometric models were estimated, including ordinary least squares estimator, censored least absolute deviations estimator, robust MM-estimator and generalised linear model, using a range of explanatory variables with KIDSCREEN-10 items scores as key predictors. The predictive performance of each model was judged using mean absolute error (MAE) and root mean squared error (RMSE). RESULTS: The MM-estimator with stepwise-selected KIDSCREEN-10 items scores as explanatory variables had the best predictive accuracy using MAE, whilst the equivalent ordinary least squares model had the best predictive accuracy using RMSE. CONCLUSIONS: The preferred mapping algorithm (i.e. the MM-estimate with stepwise selected KIDSCREEN-10 item scores as the predictors) can be used to predict CHU9D utility from KIDSCREEN-10 index with a high degree of accuracy. The algorithm may be usefully applied within cost-utility analyses to generate cost per quality adjusted life year estimates where KIDSCREEN-10 data only are available.
Keywords: Health-related quality of life; CHU9D; KIDSCREEN; mapping; utility; adolescent
Description: Published: 29 August 2014
Rights: © 2014 Chen et al.;licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
RMID: 0030098664
DOI: 10.1186/s12955-014-0134-z
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