Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115551
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Type: Journal article
Title: Effects of an antenatal dietary intervention in overweight and obese women on 6 month infant outcomes: follow-up from the LIMIT randomised trial
Author: Dodd, J.
McPhee, A.
Deussen, A.
Louise, J.
Yelland, L.
Owens, J.
Robinson, J.
Citation: International Journal of Obesity, 2018; 42(7):1326-1335
Publisher: Nature Publishing Group
Issue Date: 2018
ISSN: 0307-0565
1476-5497
Statement of
Responsibility: 
Jodie M Dodd, Andrew J McPhee, Andrea R Deussen, Jennie Louise, Lisa N Yelland, Julie A Owens, Jeffrey S Robinson
Abstract: Background: The immediate impact of providing an antenatal dietary intervention during pregnancy has been extensively studied, but little is known of the effects beyond the neonatal period. Our objective was to evaluate the effect of an antenatal dietary intervention in overweight or obese women on infant outcomes 6 months after birth. Methods: We conducted a follow up study of infants born to women who participated in the LIMIT trial during pregnancy. Live-born infants at 6-months of age, and whose mother provided consent to ongoing follow-up were eligible. The primary follow-up study endpoint was the incidence of infant BMI z-score ≥90th centile for infant sex and age. Secondary study outcomes included a range of infant anthropometric measures, neurodevelopment, general health, and infant feeding. Analyses used intention to treat principles according to the treatment group allocated in pregnancy. Missing data were imputed and analyses adjusted for maternal early pregnancy BMI, parity, study centre, socioeconomic status, age, and smoking status. Outcome assessors were blinded to the allocated treatment group. Results: A total of 1754 infants were assessed at age 6 months (Lifestyle Advice n = 869; Standard Care n = 885), representing 82.1% of the eligible sample (n = 2136). There were no statistically significant differences in the incidence of infant BMI z-score ≥90th centile for infants born to women in the Lifestyle Advice group, compared with the Standard Care group (Lifestyle Advice 233 (21.71%) vs. Standard Care 233 (21.90%); adjusted relative risk (aRR) 0.99; 95% confidence interval 0.82 to 1.18; p = 0.88). There were no other effects on infant growth, adiposity, or neurodevelopment. Conclusion: Providing pregnant women who were overweight or obese with an antenatal dietary and lifestyle intervention did not alter 6-month infant growth and adiposity. Trial Registration: Australian and New Zealand Clinical Trials Registry (ACTRN12607000161426).
Keywords: Humans; Obesity; Birth Weight; Treatment Outcome; Prenatal Care; Diet; Follow-Up Studies; Child Development; Pregnancy; Adult; Infant; Infant, Newborn; Pregnant Women; Australia; Female; Male; Overweight
Description: Published online: 30 January 2018
Rights: © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
RMID: 0030084374
DOI: 10.1038/s41366-018-0019-z
Grant ID: http://purl.org/au-research/grants/nhmrc/627005
Appears in Collections:Obstetrics and Gynaecology publications

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