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Type: Journal article
Title: Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases
Author: van den Elsen, L.
Poyntz, H.
Weyrich, L.
Young, W.
Forbes-Blom, E.
Citation: Clinical & Translational Immunology, 2017; 6(1):e125-1-e125-9
Publisher: Wiley
Issue Date: 2017
ISSN: 2050-0068
Statement of
Lieke WJ van den Elsen, Hazel C Poyntz, Laura S Weyrich, Wayne Young, Elizabeth E Forbes‐Blom
Abstract: The gut microbiota provides essential signals for the development and appropriate function of the immune system. Through this critical contribution to immune fitness, the gut microbiota has a key role in health and disease. Recent advances in the technological applications to study microbial communities and their functions have contributed to a rapid increase in host–microbiota research. Although it still remains difficult to define a so‐called ‘normal’ or ‘healthy’ microbial composition, alterations in the gut microbiota have been shown to influence the susceptibility of the host to different diseases. Current translational research combined with recent technological and computational advances have enabled in‐depth study of the link between microbial composition and immune function, addressing the interplay between the gut microbiota and immune responses. As such, beneficial modulation of the gut microbiota is a promising clinical target for many prevalent diseases including inflammatory bowel disease, metabolic abnormalities such as obesity, reduced insulin sensitivity and low‐grade inflammation, allergy and protective immunity against infections.
Rights: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Inter- national License. The images or other third party material in this article are included in the article ’ s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit nc-nd/4.0/
RMID: 0030076639
DOI: 10.1038/cti.2016.91
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