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|Title:||Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood|
|Citation:||Metabolomics, 2018; 14(10):130-1-130-3|
|John M. Wentworth, Naiara G. Bediaga, Megan A. S. Penno, Esther Bandala, Sanchez, Komal N. Kanojia, Konstantinos A. Kouremenos, Jennifer J. Couper, Leonard C. Harrison, ENDIA Study Group|
|Abstract:||Background: Cord blood lipids are potential disease biomarkers. We aimed to determine if their concentrations were affected by delayed blood processing. Method: Refrigerated cord blood from six healthy newborns was centrifuged every 12 h for 4 days. Plasma lipids were analysed by liquid chromatography/mass spectroscopy. Results: Of 262 lipids identified, only eight varied significantly over time. These comprised three dihexosylceramides, two phosphatidylserines and two phosphatidylethanolamines whose relative concentrations increased and one sphingomyelin that decreased. Conclusion: Delay in separation of plasma from refrigerated cord blood has minimal effect overall on the plasma lipidome.|
|Keywords:||Plasma lipidomics; cord blood; delayed processing; reproducibility; day-to-day variability|
|Description:||Published online: 25 September 2018|
|Rights:||© Springer Science+Business Media, LLC, part of Springer Nature 2018|
|Appears in Collections:||Paediatrics publications|
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