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Type: Journal article
Title: Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood
Author: Wentworth, J.M.
Bediaga, N.G.
Penno, M.
Bandala-Sanchez, E.
Kanojia, K.N.
Kouremenos, K.A.
Couper, J.J.
Harrison, L.C.
Citation: Metabolomics, 2018; 14(10):130-1-130-3
Publisher: Springer US
Issue Date: 2018
ISSN: 1573-3882
Statement of
John M. Wentworth, Naiara G. Bediaga, Megan A. S. Penno, Esther Bandala, Sanchez, Komal N. Kanojia, Konstantinos A. Kouremenos, Jennifer J. Couper, Leonard C. Harrison, ENDIA Study Group
Abstract: Background: Cord blood lipids are potential disease biomarkers. We aimed to determine if their concentrations were affected by delayed blood processing. Method: Refrigerated cord blood from six healthy newborns was centrifuged every 12 h for 4 days. Plasma lipids were analysed by liquid chromatography/mass spectroscopy. Results: Of 262 lipids identified, only eight varied significantly over time. These comprised three dihexosylceramides, two phosphatidylserines and two phosphatidylethanolamines whose relative concentrations increased and one sphingomyelin that decreased. Conclusion: Delay in separation of plasma from refrigerated cord blood has minimal effect overall on the plasma lipidome.
Keywords: Plasma lipidomics; cord blood; delayed processing; reproducibility; day-to-day variability
Description: Published online: 25 September 2018
Rights: © Springer Science+Business Media, LLC, part of Springer Nature 2018
RMID: 0030099647
DOI: 10.1007/s11306-018-1434-9
Grant ID:
Appears in Collections:Paediatrics publications

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