Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115597
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Type: Journal article
Title: Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood
Author: Wentworth, J.M.
Bediaga, N.G.
Penno, M.
Bandala-Sanchez, E.
Kanojia, K.N.
Kouremenos, K.A.
Couper, J.J.
Harrison, L.C.
ENDIA, S.G.
Citation: Metabolomics, 2018; 14(10):130-1-130-3
Publisher: Springer US
Issue Date: 2018
ISSN: 1573-3882
1573-3890
Statement of
Responsibility: 
John M. Wentworth, Naiara G. Bediaga, Megan A. S. Penno, Esther Bandala, Sanchez, Komal N. Kanojia, Konstantinos A. Kouremenos, Jennifer J. Couper, Leonard C. Harrison, ENDIA Study Group
Abstract: Background: Cord blood lipids are potential disease biomarkers. We aimed to determine if their concentrations were affected by delayed blood processing. Method: Refrigerated cord blood from six healthy newborns was centrifuged every 12 h for 4 days. Plasma lipids were analysed by liquid chromatography/mass spectroscopy. Results: Of 262 lipids identified, only eight varied significantly over time. These comprised three dihexosylceramides, two phosphatidylserines and two phosphatidylethanolamines whose relative concentrations increased and one sphingomyelin that decreased. Conclusion: Delay in separation of plasma from refrigerated cord blood has minimal effect overall on the plasma lipidome.
Keywords: Plasma lipidomics; cord blood; delayed processing; reproducibility; day-to-day variability
Description: Published online: 25 September 2018
Rights: © Springer Science+Business Media, LLC, part of Springer Nature 2018
RMID: 0030099647
DOI: 10.1007/s11306-018-1434-9
Grant ID: http://purl.org/au-research/grants/nhmrc/1037321
http://purl.org/au-research/grants/nhmrc/1054618
http://purl.org/au-research/grants/nhmrc/1080887
Appears in Collections:Paediatrics publications

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