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Type: Journal article
Title: Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study
Author: Ganella, E.
Seguin, C.
Pantelis, C.
Whittle, S.
Baune, B.
Olver, J.
Amminger, G.
McGorry, P.
Cropley, V.
Zalesky, A.
Bartholomeusz, C.
Citation: Australian and New Zealand Journal of Psychiatry, 2018; 52(9):864-875
Publisher: SAGE Publications
Issue Date: 2018
ISSN: 0004-8674
Statement of
Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky and Cali F Bartholomeusz
Abstract: Introduction: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, reports of network abnormalities during the early illness stage of psychosis are mixed. This study adopted a data-driven whole-brain approach to investigate functional connectivity and network architecture in a first-episode psychosis cohort relative to healthy controls and whether functional network properties changed abnormally over a 12-month period in first-episode psychosis. Methods: Resting-state functional connectivity was performed at two time points. At baseline, 29 first-episode psychosis individuals and 30 healthy controls were assessed, and at 12 months, 14 first-episode psychosis individuals and 20 healthy controls completed follow-up. Whole-brain resting-state functional connectivity networks were mapped for each individual and analyzed using graph theory to investigate whether network abnormalities associated with first-episode psychosis were evident and whether functional network properties changed abnormally over 12 months relative to controls. Results: This study found no evidence of abnormal resting-state functional connectivity or topology in first-episode psychosis individuals relative to healthy controls at baseline or at 12-months follow-up. Furthermore, longitudinal changes in network properties over a 12-month period did not significantly differ between first-episode psychosis individuals and healthy control. Network measures did not significantly correlate with symptomatology, duration of illness or antipsychotic medication. Conclusions: This is the first study to show unaffected resting-state functional connectivity and topology in the early psychosis stage of illness. In light of previous literature, this suggests that a subgroup of first-episode psychosis individuals who have a neurotypical resting-state functional connectivity and topology may exist. Our preliminary longitudinal analyses indicate that there also does not appear to be deterioration in these network properties over a 12-month period. Future research in a larger sample is necessary to confirm our longitudinal findings.
Keywords: Resting state; first episode of psychosis; functional connectivity; graph theory
Rights: © The Royal Australian and New Zealand College of Psychiatrists 2018
RMID: 0030090363
DOI: 10.1177/0004867418775833
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Appears in Collections:Psychiatry publications

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