Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115635
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Type: Journal article
Title: The mediating effects of gestational diabetes on fetal growth and adiposity in women who are overweight and obese: secondary analysis of the LIMIT randomised trial
Author: Poprzeczny, A.
Louise, J.
Deussen, A.
Dodd, J.
Citation: BJOG: An International Journal of Obstetrics and Gynaecology, 2018; 125(12):1558-1566
Publisher: Wiley
Issue Date: 2018
ISSN: 1470-0328
1471-0528
Statement of
Responsibility: 
AJ Poprzeczny, J Louise, AR Deussen, JM Dodd
Abstract: Objective: To describe the mediating effect of maternal gestational diabetes on fetal biometry and adiposity measures among overweight or obese pregnant women. Design: Secondary analysis of the LIMIT randomised trial. Setting: Public hospitals, metropolitan Adelaide, South Australia. Population: Pregnant women with body mass index (BMI) ≥25 kg/m2 and singleton gestation. Methods: Fetal ultrasound measures at 36 weeks of gestation and baseline BMI from women randomised to the LIMIT trial Standard Care group (n = 912 women) were used to conduct causal mediation analyses using regression‐based methods. Main outcomes measures: Ultrasound measures of fetal biometry and adiposity at 36 weeks of gestation. Results: Increased maternal BMI was associated with increased measures of fetal head circumference [direct (unmediated) effect 0.18 (95% CI: 0.05–0.31), P = 0.005; total effect 0.17 (95% CI: 0.02–0.31), P = 0.018], abdominal circumference [direct effect 0.26 (95% CI: 0.11–0.41), P = 0.001; total effect 0.26 (95% CI: 0.11–0.42), P = 0.001] and estimated fetal weight [direct effect 0.22 (95% CI: 0.08–0.35), P = 0.002; total effect 0.22 (95% CI: 0.08–0.35), P = 0.002], with no evidence of mediation by treated gestational diabetes. There was no apparent association between maternal BMI and fetal adiposity measures, or mediation by treated gestational diabetes. Conclusions: We show an important association between increased maternal BMI and fetal growth, not mediated by treated gestational diabetes. There was no association between increased maternal BMI and fetal adiposity measures, or mediation by treated gestational diabetes. Whether these findings represent ‘saturation’ in the effect of maternal BMI on fetal growth or the effect of treatment of GDM is unclear.
Keywords: fetal adiposity; fetal growth; fetal ultrasound; gestational diabetes; maternal obesity
Description: Published Online 14 June 2018
Rights: © 2018 Royal College of Obstetricians and Gynaecologists
RMID: 0030088773
DOI: 10.1111/1471-0528.15288
Grant ID: http://purl.org/au-research/grants/nhmrc/519240
Appears in Collections:Obstetrics and Gynaecology publications

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