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Type: Journal article
Title: Eph/ephrin-mediated mesenchymal stem cell regulation of T-cell activation and function
Author: M Nguyen, T.
Arthur, A.
Gronthos, S.
Citation: Journal of Clinical and Cellular Immunology, 2016; 7(3):418-1-418-7
Publisher: OMICS International
Issue Date: 2016
ISSN: 2155-9899
Statement of
Thao M. Nguyen, Agnieszka Arthur and Stan Gronthos
Abstract: Mesenchymal stem cells (MSC) represent a promising cellular therapy for the treatment of immune-related conditions due to their immunomodulatory properties, which include the capacity to inhibit the proliferation and function of T-cells. Despite the fact that MSC have been the subject of intense investigation as therapeutic agents for diseases in which cellular immune response is exacerbated, the underlying mechanisms of how MSC exert their Tcell suppressive properties remain to be fully understood. Eph surface tyrosine kinase receptors and their ephrin ligands are involved in T-cell development, maturation, activation and proliferation. Recent findings have demonstrated Eph/ephrin interactions as potential mechanisms mediating human MSC inhibition of activated T-cells. Here we highlight the influence of Eph and ephrin molecules in the communication between MSC and T-cells that result in T-cell suppression by MSC.
Rights: © 2016 Nguyen TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030061082
DOI: 10.4172/2155-9899.1000418
Grant ID:
Appears in Collections:Medicine publications

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