Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115815
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dc.contributor.authorM Nguyen, T.en
dc.contributor.authorArthur, A.en
dc.contributor.authorGronthos, S.en
dc.date.issued2016en
dc.identifier.citationJournal of Clinical and Cellular Immunology, 2016; 7(3):418-1-418-7en
dc.identifier.issn2155-9899en
dc.identifier.issn2155-9899en
dc.identifier.urihttp://hdl.handle.net/2440/115815-
dc.description.abstractMesenchymal stem cells (MSC) represent a promising cellular therapy for the treatment of immune-related conditions due to their immunomodulatory properties, which include the capacity to inhibit the proliferation and function of T-cells. Despite the fact that MSC have been the subject of intense investigation as therapeutic agents for diseases in which cellular immune response is exacerbated, the underlying mechanisms of how MSC exert their Tcell suppressive properties remain to be fully understood. Eph surface tyrosine kinase receptors and their ephrin ligands are involved in T-cell development, maturation, activation and proliferation. Recent findings have demonstrated Eph/ephrin interactions as potential mechanisms mediating human MSC inhibition of activated T-cells. Here we highlight the influence of Eph and ephrin molecules in the communication between MSC and T-cells that result in T-cell suppression by MSC.en
dc.description.statementofresponsibilityThao M. Nguyen, Agnieszka Arthur and Stan Gronthosen
dc.language.isoenen
dc.publisherOMICS Internationalen
dc.rights© 2016 Nguyen TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.titleEph/ephrin-mediated mesenchymal stem cell regulation of T-cell activation and functionen
dc.typeJournal articleen
dc.identifier.rmid0030061082en
dc.identifier.doi10.4172/2155-9899.1000418en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1083704en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1042677en
dc.identifier.pubid283184-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidArthur, A. [0000-0002-0539-8797]en
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]en
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