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Type: Journal article
Title: CETP Inhibition in CVD prevention: an actual appraisal
Author: Di Bartolo, B.
Takata, K.
Duong, M.
Nicholls, S.
Citation: Current Cardiology Reports, 2016; 18(5):43-1-43-6
Publisher: Springer
Issue Date: 2016
ISSN: 1523-3782
Statement of
Belinda Di Bartolo, Kohei Takata, MyNgan Duong, Stephen J. Nicholls
Abstract: By virtue of their effects on low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and cellular cholesterol efflux, there is considerable interest in the potential use of pharmacological inhibitors of cholesteryl ester transfer protein (CETP) as a novel approach for cardiovascular disease prevention. This is supported by observations from genetic and animal studies suggesting that less CETP activity has favorable cardiovascular effects. Despite the adverse effects of the first CETP inhibitor to move forward in clinical development, torcetrapib, there remains considerable interest in developing alternative CETP inhibitors without the off-target effects of torcetrapib. The clinical development programs leading to a number of promising CETP inhibitors will be reviewed.
Keywords: CETP inhibitors; lipids; cardiovascular disease; prevention; clinical trials
Rights: © Springer Science+Business Media New York 2016
RMID: 0030046581
DOI: 10.1007/s11886-016-0724-y
Appears in Collections:Agriculture, Food and Wine publications

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