Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115834
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dc.contributor.authorDi Bartolo, B.en
dc.contributor.authorTakata, K.en
dc.contributor.authorDuong, M.en
dc.contributor.authorNicholls, S.en
dc.date.issued2016en
dc.identifier.citationCurrent Cardiology Reports, 2016; 18(5):43-1-43-6en
dc.identifier.issn1523-3782en
dc.identifier.issn1534-3170en
dc.identifier.urihttp://hdl.handle.net/2440/115834-
dc.description.abstractBy virtue of their effects on low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and cellular cholesterol efflux, there is considerable interest in the potential use of pharmacological inhibitors of cholesteryl ester transfer protein (CETP) as a novel approach for cardiovascular disease prevention. This is supported by observations from genetic and animal studies suggesting that less CETP activity has favorable cardiovascular effects. Despite the adverse effects of the first CETP inhibitor to move forward in clinical development, torcetrapib, there remains considerable interest in developing alternative CETP inhibitors without the off-target effects of torcetrapib. The clinical development programs leading to a number of promising CETP inhibitors will be reviewed.en
dc.description.statementofresponsibilityBelinda Di Bartolo, Kohei Takata, MyNgan Duong, Stephen J. Nichollsen
dc.language.isoenen
dc.publisherSpringeren
dc.rights© Springer Science+Business Media New York 2016en
dc.subjectCETP inhibitors; lipids; cardiovascular disease; prevention; clinical trialsen
dc.titleCETP Inhibition in CVD prevention: an actual appraisalen
dc.typeJournal articleen
dc.identifier.rmid0030046581en
dc.identifier.doi10.1007/s11886-016-0724-yen
dc.identifier.pubid243259-
pubs.library.collectionAgriculture, Food and Wine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidDi Bartolo, B. [0000-0001-8420-0461]en
dc.identifier.orcidDuong, M. [0000-0002-9542-1187]en
dc.identifier.orcidNicholls, S. [0000-0002-9668-4368]en
Appears in Collections:Agriculture, Food and Wine publications

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