Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Current Osteoporosis Reports, 2017; 15(5):433-442||en|
|dc.description.abstract||Purpose of Review: This review assembles recent understanding of the profound loss of muscle and bone in spinal cord injury (SCI). It is important to try to understand these changes, and the context in which they occur, because of their impact on the wellbeing of SC-injured individuals, and the urgent need for viable preventative therapies. Recent Findings: Recent research provides new understanding of the effects of age and systemic factors on the response of bone to loading, of relevance to attempts to provide load therapy for bone in SCI. The rapidly growing dataset describing the biochemical crosstalk between bone and muscle, and the cell and molecular biology of myokines signalling to bone and osteokines regulating muscle metabolism and mass, is reviewed. The ways in which this crosstalk may be altered in SCI is summarised. Summary: Therapeutic approaches to the catabolic changes in muscle and bone in SCI require a holistic understanding of their unique mechanical and biochemical context.||en|
|dc.description.statementofresponsibility||Jillian M. Clark, David M. Findlay||en|
|dc.rights||© Springer Science+Business Media, LLC 2017||en|
|dc.subject||Spinal cord injury; bone; muscle; bone loading; myokines; osteokines||en|
|dc.title||Musculoskeletal health in the context of spinal cord injury||en|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.