Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115853
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dc.contributor.authorClark, J.en
dc.contributor.authorFindlay, D.en
dc.date.issued2017en
dc.identifier.citationCurrent Osteoporosis Reports, 2017; 15(5):433-442en
dc.identifier.issn1544-1873en
dc.identifier.issn1544-2241en
dc.identifier.urihttp://hdl.handle.net/2440/115853-
dc.description.abstractPurpose of Review: This review assembles recent understanding of the profound loss of muscle and bone in spinal cord injury (SCI). It is important to try to understand these changes, and the context in which they occur, because of their impact on the wellbeing of SC-injured individuals, and the urgent need for viable preventative therapies. Recent Findings: Recent research provides new understanding of the effects of age and systemic factors on the response of bone to loading, of relevance to attempts to provide load therapy for bone in SCI. The rapidly growing dataset describing the biochemical crosstalk between bone and muscle, and the cell and molecular biology of myokines signalling to bone and osteokines regulating muscle metabolism and mass, is reviewed. The ways in which this crosstalk may be altered in SCI is summarised. Summary: Therapeutic approaches to the catabolic changes in muscle and bone in SCI require a holistic understanding of their unique mechanical and biochemical context.en
dc.description.statementofresponsibilityJillian M. Clark, David M. Findlayen
dc.language.isoenen
dc.publisherSpringeren
dc.rights© Springer Science+Business Media, LLC 2017en
dc.subjectSpinal cord injury; bone; muscle; bone loading; myokines; osteokinesen
dc.titleMusculoskeletal health in the context of spinal cord injuryen
dc.typeJournal articleen
dc.identifier.rmid0030074866en
dc.identifier.doi10.1007/s11914-017-0400-1en
dc.identifier.pubid368401-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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