Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Characterization of esophageal physiology using mechanical state analysis
Author: Leibbrandt, R.
Dinning, P.
Costa, M.
Cock, C.
Wiklendt, L.
Wang, G.
Tack, J.
Van Beckevoort, D.
Rommel, N.
Omari, T.
Citation: Frontiers in Systems Neuroscience, 2016; 10(FEB):10-1-10-13
Publisher: Frontiers Media SA
Issue Date: 2016
ISSN: 1662-5137
Statement of
Richard E. Leibbrandt, Phil G. Dinning, Marcello Costa, Charles Cock, Lukasz Wiklendt, Guangsong Wang, Jan Tack, Dirk van Beckevoort, Nathalie Rommel and Taher I. Omari
Abstract: The esophagus functions to transport swallowed fluids and food from the pharynx to the stomach. The esophageal muscles governing bolus transport comprise circular striated muscle of the proximal esophagus and circular smooth muscle of the distal esophagus. Longitudinal smooth muscle contraction provides a mechanical advantage to bolus transit during circular smooth muscle contraction. Esophageal striated muscle is directly controlled by neural circuits originating in the central nervous system, resulting in coordinated contractions. In contrast, the esophageal smooth muscle is controlled by enteric circuits modulated by extrinsic central neural connections resulting in neural relaxation and contraction. The esophageal muscles are modulated by sensory information arising from within the lumen. Contraction or relaxation, which changes the diameter of the lumen, alters the intraluminal pressure and ultimately inhibits or promotes flow of content. This relationship that exists between the changes in diameter and concurrent changes in intraluminal pressure has been used previously to identify the "mechanical states" of the circular muscle; that is when the muscles are passively or actively, relaxing or contracting. Detecting these changes in the mechanical state of the muscle has been difficult and as the current interpretation of esophageal motility is based largely upon pressure measurement (manometry), subtle changes in the muscle function during peristalsis can be missed. We hypothesized that quantification of mechanical states of the esophageal circular muscles and the pressure-diameter properties that define them, would allow objective characterization of the mechanisms that govern esophageal peristalsis. To achieve this we analyzed barium swallows captured by simultaneous videofluoroscopy and pressure with impedance recording. From these data we demonstrated that intraluminal impedance measurements could be used to determine changes in the internal diameter of the lumen comparable with measurements from videofluoroscopy. Our data indicated that identification of mechanical state of esophageal muscle was simple to apply and revealed patterns consistent with the known neural inputs activating the different muscles during swallowing.
Keywords: Esophageal peristalsis; swallow; dysphagia; pressure; impedance; neural pathways
Rights: © 2016 Leibbrandt, Dinning, Costa, Cock, Wiklendt, Wang, Tack, van Beckevoort, Rommel and Omari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030045278
DOI: 10.3389/fnsys.2016.00010
Appears in Collections:Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_115862.pdfPublished Version3.93 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.