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Type: Journal article
Title: Coordination of ovulation and oocyte maturation: a good egg at the right time
Author: Robker, R.
Hennebold, J.
Russell, D.
Citation: Endocrinology, 2018; 159(9):3209-3218
Publisher: Endocrine Society
Issue Date: 2018
ISSN: 0013-7227
Statement of
Rebecca L Robker, Jon D Hennebold, Darryl L Russell
Abstract: Ovulation is the appropriately timed release of a mature, developmentally competent oocyte from the ovary into the oviduct, where fertilization occurs. Importantly, ovulation is tightly linked with oocyte maturation, demonstrating the interdependency of these two parallel processes, both essential for female fertility. Initiated by pituitary gonadotropins, the ovulatory process is mediated by intrafollicular paracrine factors from the theca, mural, and cumulus granulosa cells, as well as the oocyte itself. The result is the induction of cumulus expansion, proteolysis, angiogenesis, inflammation, and smooth muscle contraction, which are each required for follicular rupture. These complex intercellular communication networks and the essential ovulatory genes have been well defined in mouse models and are highly conserved in primates, including humans. Importantly, recent discoveries in regulation of ovulation highlight new areas of investigation.
Keywords: Muscle, Smooth; Ovarian Follicle; Theca Cells; Oocytes; Animals; Primates; Humans; Mice; Follicle Stimulating Hormone; Luteinizing Hormone; Ovulation; Neovascularization, Physiologic; Muscle Contraction; Time Factors; Female; Cumulus Cells; Proteolysis
Rights: © 2018 Endocrine Society
RMID: 0030099294
DOI: 10.1210/en.2018-00485
Appears in Collections:Agriculture, Food and Wine publications

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