Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/115886
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Type: Journal article
Title: Coordination of ovulation and oocyte maturation: a good egg at the right time
Author: Robker, R.
Hennebold, J.
Russell, D.
Citation: Endocrinology, 2018; 159(9):3209-3218
Publisher: Endocrine Society
Issue Date: 2018
ISSN: 0013-7227
1945-7170
Statement of
Responsibility: 
Rebecca L Robker, Jon D Hennebold, Darryl L Russell
Abstract: Ovulation is the appropriately timed release of a mature, developmentally competent oocyte from the ovary into the oviduct, where fertilization occurs. Importantly, ovulation is tightly linked with oocyte maturation, demonstrating the interdependency of these two parallel processes, both essential for female fertility. Initiated by pituitary gonadotropins, the ovulatory process is mediated by intrafollicular paracrine factors from the theca, mural, and cumulus granulosa cells, as well as the oocyte itself. The result is the induction of cumulus expansion, proteolysis, angiogenesis, inflammation, and smooth muscle contraction, which are each required for follicular rupture. These complex intercellular communication networks and the essential ovulatory genes have been well defined in mouse models and are highly conserved in primates, including humans. Importantly, recent discoveries in regulation of ovulation highlight new areas of investigation.
Keywords: Muscle, Smooth
Ovarian Follicle
Theca Cells
Oocytes
Animals
Primates
Humans
Mice
Follicle Stimulating Hormone
Luteinizing Hormone
Ovulation
Neovascularization, Physiologic
Muscle Contraction
Time Factors
Female
Cumulus Cells
Proteolysis
Rights: © 2018 Endocrine Society
DOI: 10.1210/en.2018-00485
Grant ID: NHMRC
Appears in Collections:Agriculture, Food and Wine publications
Aurora harvest 8

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