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Type: Journal article
Title: Copy number variations of CBF genes at the Fr-A2 locus are essential components of winter hardiness in wheat
Author: Würschum, T.
Longin, C.
Hahn, V.
Tucker, M.
Leiser, W.
Citation: Plant Journal, 2017; 89(4):764-773
Publisher: Wiley
Issue Date: 2017
ISSN: 0960-7412
Statement of
Tobias Würschum, C. Friedrich H. Longin, Volker Hahn, Matthew R. Tucker, Willmar L. Leiser
Abstract: Winter hardiness is important for the adaptation of wheat to the harsh winter conditions in temperate regions and is thus also an important breeding goal. Here, we employed a panel of 407 European winter wheat cultivars to dissect the genetic architecture of winter hardiness. We show that copy number variation (CNV) of CBF genes at the Fr-A2 locus is the essential component for winter survival, with CBF-A14 CNV being the most likely causal polymorphism, accounting for 24.3% of the genotypic variance. Genome-wide association mapping identified several markers in the Fr-A2 chromosomal region, which even after accounting for the effects of CBF-A14 copy number explained approximately 15% of the genotypic variance. This suggests that additional, as yet undiscovered polymorphisms are present at the Fr-A2 locus. Furthermore, copy number variation of Vrn-A1 explained an additional 3.0% of the genotypic variance. The allele frequencies of all loci associated with winter hardiness were found to show geographic patterns consistent with their role in adaptation. Collectively, our results from the candidate gene analysis, association mapping and genome-wide prediction show that winter hardiness in wheat is a quantitative trait, but with a major contribution of the Fr-A2 locus. This article is protected by copyright. All rights reserved.
Keywords: Fr-A2; Vrn-A1; association mapping; copy number variation; wheat; winter hardiness
Rights: © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.
RMID: 0030058457
DOI: 10.1111/tpj.13424
Appears in Collections:Agriculture, Food and Wine publications

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