Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/115902
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Type: Journal article
Title: Diatom silica for biomedical applications: recent progress and advances
Author: Maher, S.
Kumeria, T.
Aw, M.
Losic, D.
Citation: Advanced Healthcare Materials, 2018; 7(19):1800552-1-1800552-19
Publisher: Wiley
Issue Date: 2018
ISSN: 2192-2640
2192-2659
Statement of
Responsibility: 
Shaheer Maher, Tushar Kumeria, Moom Sin Aw, and Dusan Losic
Abstract: Diatoms are unicellular photosynthetic algae enclosed in porous 3D nanopatterned silica enclosures called "frustules." The diatom frustules are made from biosilica self-assembled into intricate porous shells that feature unique properties including high specific surface area, biocompatibility, tailorable surface chemistry, thermal stability, and high mechanical and chemical resistance. The ability to cultivate diatoms in artificial environments and their abundant availability of diatom frustules as mineable fossilized mineral deposits (diatomite or diatomaceous earth; DE) make diatom silica a promising natural alternative to synthetic porous silica for a broad range of biomedical, environmental, agricultural, and energy applications. This review article provides a comprehensive and current account of the use of natural DE silica materials in biomedical applications focused mainly on drug delivery with some highlights on biosensing, tissue engineering, and clotting agents. The article also covers some basic physical and chemical aspects of DE material such as purification, surface chemical functionalization, biocompatibility, and cellular uptake that are critical for the development of an efficient drug carrier.
Keywords: DE frustules; diatom silica; diatomaceous earth; diatoms; drug delivery
Description: Published online: August 17, 2018
Rights: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0030097130
DOI: 10.1002/adhm.201800552
Grant ID: http://purl.org/au-research/grants/arc/DP120101680
http://purl.org/au-research/grants/arc/FT110100711
http://purl.org/au-research/grants/nhmrc/1143296
Appears in Collections:Chemical Engineering publications

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