Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11601
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Type: Journal article
Title: Investigation of the taxonomy and systematics of Fusobacterium nucleatum using allozyme electrophoresis
Author: Morris, M.
Andrews, R.
Rogers, A.
Citation: International Journal of Systematic Bacteriology, 1997; 47(1):103-110
Publisher: International Union of Microbiological Societies
Issue Date: 1997
ISSN: 1466-5026
1465-2102
Statement of
Responsibility: 
Michelle L. Morris, R. H. Andrews, and A. H. Rogers
Abstract: Fusobacterium nucleatum forms part of the resident microbiota in both oral and extraoral sites in humans and animals. It is also involved in infections in such sites. Despite the genetic heterogeneity within the species, it has been divided into five subspecies, the validities of which have been questioned. In the present study, 44 F. nucleatum isolates were examined at 21 enzyme loci by using the allozyme electrophoretic technique to establish an accurate genetic framework for taxonomic purposes. Three distinct genetic clusters were identified; one cluster consisted exclusively of extraoral isolates, another cluster consisted predominantly of human oral isolates, and the third cluster consisted of a single human oral isolate. Our results highlight the urgent need for extensive biochemical, immunological, and epidemiological studies to accurately define the systematics of the genus Fusobacterium based on the framework derived in this study by using 21 independent genetic characteristics.
Keywords: Humans; Fusobacterium nucleatum; Fusobacterium Infections; Enzymes; DNA, Bacterial; Electrophoresis, Cellulose Acetate; Bacteriological Techniques; Phylogeny; Alleles; Genetic Variation
Rights: Copyright © 1997, International Union of Microbiological Societies
RMID: 0030004210
DOI: 10.1099/00207713-47-1-103
Appears in Collections:Microbiology and Immunology publications

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