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Type: Journal article
Title: Biofilm and osteitis in refractory chronic rhinosinusitis
Author: Zhao, Y.
Wormald, P.
Citation: Otolaryngologic Clinics of North America, 2017; 50(1):49-60
Publisher: Elsevier
Issue Date: 2017
ISSN: 0030-6665
Statement of
Yi Chen Zhao and Peter-John Wormald
Abstract: Our understanding of chronic rhinosinusitis (CRS) show biofilm and osteitis play a role in the disease's pathogenesis and refractory. Studies point to its role in pathogenesis and poor prognosis. Outside the research laboratory, biofilm detection remains difficult and specific treatment remains elusive. It is believed that osteitis is a nidus of inflammation and occurs more commonly in patients with refractory CRS. However, osteitis may be exacerbated by surgery and a marker of refractory disease, not a causative agent. Surgery remains the mainstay treatment for biofilm and osteitis with mechanical disruption and removal of disease load providing the most effective treatment.
Keywords: Biofilm; osteitis; refractory rhinosinusitis; endoscopic surgery
Rights: © 2016 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.otc.2016.08.005
Published version:
Appears in Collections:Aurora harvest 8
Surgery publications

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