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https://hdl.handle.net/2440/116167
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dc.contributor.author | Andrew, N.H. | - |
dc.contributor.author | Kearney, D. | - |
dc.contributor.author | Sladden, N. | - |
dc.contributor.author | McKelvie, P. | - |
dc.contributor.author | Wu, A. | - |
dc.contributor.author | Sun, M.T. | - |
dc.contributor.author | McNab, A. | - |
dc.contributor.author | Selva, D. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | American Journal of Ophthalmology, 2016; 163:148-153.e1 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.issn | 1879-1891 | - |
dc.identifier.uri | http://hdl.handle.net/2440/116167 | - |
dc.description.abstract | Purpose: To review the clinical and histologic features of idiopathic dacryoadenitis, and to assess prognostic factors associated with disease recurrence, treatment recalcitrance, and incomplete treatment response. Design: Retrospective interventional case series. Methods: setting: Tertiary referral centers. patients: Seventy-nine cases of biopsy-confirmed idiopathic dacryoadenitis. observation procedures: The following data were reviewed: age, sex, laterality, symptom onset, clinical presentation, histopathology, treatment response, and recurrence. main outcome measures: Rates of treatment recalcitrance, incomplete treatment response, and recurrence. Results: Idiopathic dacryoadenitis patients had a mean age of 50 years, 57% were female, and 16% of cases were bilateral. Fifty-two percent had inflammation extending to adjacent structures on imaging. Twenty percent were recalcitrant to treatment, 17% had an incomplete treatment response, and 15% of patients had a recurrence during a mean follow-up time of 64 months. Risk factors for an incomplete treatment response were male sex (P = .01) and inflammation extending to extraocular muscle (P = .01). A clinical presentation of "classic" dacryoadenitis was a risk factor for treatment recalcitrance (P = .02). Bilateral cases were younger than unilateral cases (P = .004) and had an increased risk of recurrence (P = .05). Sclerosing cases were associated with an insidious onset of symptoms (P = .009), but neither histopathology nor the speed of symptom onset was associated with a poor prognosis. Conclusion: Thirty-seven percent of idiopathic dacryoadenitis had a poor response to treatment and 15% of cases recurred. The prognostic factors identified in this study have not been reported previously and may inform management. | - |
dc.description.statementofresponsibility | Nicholas H. Andrew, Daniel Kearney, Nicole Sladden, Penny McKelvie, Albert Wu, Michele T. Sun, Alan McNab and Dinesh Selva | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2016 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.ajo.2015.11.032 | - |
dc.subject | Dacryocystitis; treatment outcomes | - |
dc.title | Idiopathic dacryoadenitis: clinical features, histopathology, and treatment outcomes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ajo.2015.11.032 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selva, D. [0000-0002-2169-5417] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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