Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/116204
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Type: Journal article
Title: A quantification of regenerated bone tissue in human sinus biopsies: influences of anatomical region, age and sex
Author: Reich, K.M.
Huber, C.D.
Heimel, P.
Ulm, C.
Redl, H.
Tangl, S.
Citation: Clinical Oral Implants Research, 2016; 27(5):583-590
Publisher: Wiley
Issue Date: 2016
ISSN: 0905-7161
1600-0501
Statement of
Responsibility: 
Karoline Maria Reich, Christian Domitian Huber, Patrick Heimel, Christian Ulm, Heinz Redl, Stefan Tangl
Abstract: Objectives: Sinus augmentation is a standard procedure to increase vertical bone supply for dental implants in the atrophic posterior maxilla. Despite the longstanding application of this method, information about some basic factors that could potentially influence bone regeneration after sinus augmentation is rare. The objective of this study was therefore to quantify the impact of the maxillary region (premolar/molar) and patients' age and sex on bone regeneration after sinus grafting. Material and methods: Sinus augmentation procedures were performed in 107 patients (66 female: 52.8 ± 11.0 years, 41 male: 50.6 ± 11.3 years). After 6 ± 1 months, 201 sinus biopsies were harvested and histomorphometrically analysed. Height (oldHt) and bone volume fraction of pristine bone (oldBV/TV), as well as the amount of new bone (newBV/TV) and bone‐to‐bone substitute contact (BBSC) in the augmentation area, were assessed. Results: In women, newBV/TV in the augmented sinus decreased significantly by 0.22 ± 0.08% per year. In men, no similar trend was observed. There were strong influences of the maxillary region and the dimensions of the host bone. In the premolar region, newBV/TV was 23.1 ± 7.9% and 25.1 ± 10.1%; in the molar region, newBV/TV averaged 20.4 ± 9.4% and 17.8 ± 8.8% for women and men, respectively. The greater the thickness of the wall of the sinus floor (mainly in the former premolar region), the greater was the amount of new bone tissue formed in the spaces in‐between bone substitute particles. Conclusions: These empirical results derived from a large human sample, link factors that influence the quality of biomaterial integration to the known clinical risks for the success of dental implants.
Keywords: Age- and sex-dependency; bone quality; bone regeneration potential; bone substitute material; maxillary region; sinus augmentation
Rights: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/clr.12627
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