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Type: Journal article
Title: Irinotecan-induced mucositis: the interactions and potential role of GLP-2 analogues
Author: Mayo, B.
Stringer, A.
Bowen, J.
Bateman, E.
Keefe, D.
Citation: Cancer Chemotherapy and Pharmacology, 2017; 79(2):233-249
Publisher: Springer
Issue Date: 2017
ISSN: 0344-5704
Statement of
Bronwen J. Mayo, Andrea M. Stringer, Joanne M. Bowen, Emma H. Bateman, Dorothy M. Keefe
Abstract: Purpose: A common side effect of irinotecan administration is gastrointestinal mucositis, often manifesting as severe diarrhoea. The damage to the structure and function of the gastrointestinal tract caused by this cytotoxic agent is debilitating and often leads to alterations in patients’ regimens, hospitalisation or stoppage of treatment. The purpose of this review is to identify mechanisms of irinotecan induced intestinal damage and a potential role for GLP-2 analogues for intervention. Methods: This is a review of current literature on irinotecan-induced mucositis and GLP-2 analogues mechanisms of action. Results: Recent studies have found alterations that appear to be crucial in the development of severe intestinal mucositis, including early apoptosis, alterations in proliferation and cell survival pathways, as well as induction of inflammatory cascades. Several studies have indicated a possible role for glucagon-like peptide-2 analogues in treating this toxicity, due to its proven intestinotrophic, anti-apoptotic and anti-inflammatory effects in other models of gastrointestinal disease. Conclusion: This review provides evidence as to why and how this treatment may improve mucositis through the possible molecular crosstalk that may be occurring in models of severe intestinal mucositis.
Keywords: Gastrointestinal mucositis; irinotecan; glucagon-like peptide-2; apoptosis; proliferation; inflammation
Rights: © Springer-Verlag Berlin Heidelberg 2016
RMID: 0030057152
DOI: 10.1007/s00280-016-3165-9
Appears in Collections:Medicine publications

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