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Type: Journal article
Title: Effects of age, gender and statin dose on lipid levels: results from the VOYAGER meta-analysis database
Author: Karlson, B.
Palmer, M.
Nicholls, S.
Barter, P.
Lundman, P.
Citation: Atherosclerosis, 2017; 265:54-59
Publisher: Elsevier
Issue Date: 2017
ISSN: 0021-9150
Statement of
Björn W. Karlson, Michael K. Palmer, Stephen J. Nicholls, Philip J. Barter, Pia Lundman
Abstract: Background and aims: The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. However, the association of statin-mediated lipid effects with age and gender is unclear. This study aimed to determine whether age and gender are associated with statin-mediated changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL-C. Methods: Individual patient data (n = 32,258) were obtained from VOYAGER. Least-squares mean percentage change from baseline in LDL-C, non-HDL-C and HDL-C with atorvastatin 10-80 mg, rosuvastatin 5-40 mg or simvastatin 10-80 mg was estimated in women aged <70 years, women aged ≥70 years, men aged <70 years and men aged ≥70 years. Results: All statins and doses gave significant dose-dependent reductions in LDL-C and non-HDL-C, and increases in HDL-C, in all four patient groups. A 2.1% greater reduction in LDL-C was observed in women, compared with men (p < 0.0001). Patients aged ≥70 years experienced a 2.7% greater reduction in LDL-C compared with younger patients (p < 0.0001). Similar results were also observed for statin-mediated changes in non-HDL-C. Men experienced a significantly greater increase in HDL-C than women, and patients aged ≥70 years achieved a significantly greater increase than younger patients (both p = 0.001). Conclusions: While statins improve the lipid profile in all gender and age groups analysed, the improvements are greater in women than in men and in those aged ≥70 years compared with those aged <70 years.
Keywords: Age; dyslipidaemia; elderly; gender; statins; women
Rights: © 2017 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.atherosclerosis.2017.08.014
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