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https://hdl.handle.net/2440/116435
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dc.contributor.author | Karlson, B. | - |
dc.contributor.author | Palmer, M. | - |
dc.contributor.author | Nicholls, S. | - |
dc.contributor.author | Barter, P. | - |
dc.contributor.author | Lundman, P. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Atherosclerosis, 2017; 265:54-59 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.issn | 1879-1484 | - |
dc.identifier.uri | http://hdl.handle.net/2440/116435 | - |
dc.description.abstract | Background and aims: The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. However, the association of statin-mediated lipid effects with age and gender is unclear. This study aimed to determine whether age and gender are associated with statin-mediated changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL-C. Methods: Individual patient data (n = 32,258) were obtained from VOYAGER. Least-squares mean percentage change from baseline in LDL-C, non-HDL-C and HDL-C with atorvastatin 10-80 mg, rosuvastatin 5-40 mg or simvastatin 10-80 mg was estimated in women aged <70 years, women aged ≥70 years, men aged <70 years and men aged ≥70 years. Results: All statins and doses gave significant dose-dependent reductions in LDL-C and non-HDL-C, and increases in HDL-C, in all four patient groups. A 2.1% greater reduction in LDL-C was observed in women, compared with men (p < 0.0001). Patients aged ≥70 years experienced a 2.7% greater reduction in LDL-C compared with younger patients (p < 0.0001). Similar results were also observed for statin-mediated changes in non-HDL-C. Men experienced a significantly greater increase in HDL-C than women, and patients aged ≥70 years achieved a significantly greater increase than younger patients (both p = 0.001). Conclusions: While statins improve the lipid profile in all gender and age groups analysed, the improvements are greater in women than in men and in those aged ≥70 years compared with those aged <70 years. | - |
dc.description.statementofresponsibility | Björn W. Karlson, Michael K. Palmer, Stephen J. Nicholls, Philip J. Barter, Pia Lundman | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2017 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.atherosclerosis.2017.08.014 | - |
dc.subject | Age; dyslipidaemia; elderly; gender; statins; women | - |
dc.title | Effects of age, gender and statin dose on lipid levels: results from the VOYAGER meta-analysis database | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2017.08.014 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Nicholls, S. [0000-0002-9668-4368] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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