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dc.contributor.authorMouton, J.-
dc.contributor.authorMuller, A.-
dc.contributor.authorCanton, R.-
dc.contributor.authorGiske, C.-
dc.contributor.authorKahlmeter, G.-
dc.contributor.authorTurnidge, J.-
dc.identifier.citationJournal of Antimicrobial Chemotherapy, 2018; 73(3):564-568-
dc.description.abstractOver recent decades, several publications have described optimization procedures for antibiotic therapy in the individual patient based on antimicrobial MIC values. Most methods include therapeutic drug monitoring and use a single MIC determination plus the relevant pharmacokinetics/pharmacodynamics to adjust the dose to optimize antimicrobial drug exposure and antibacterial effects. However, the use of an MIC obtained by a single MIC determination is inappropriate. First, routine clinical laboratories cannot determine MICs with sufficient accuracy to guide dosage owing to the inherent assay variation in the MIC test. Second, the variation in any MIC determination, whatever method is used, must be accounted for. If dose adjustments are made based on therapeutic drug monitoring and include MIC determinations, MIC variation must be considered to prevent potential underdosing of patients. We present the problems and some approaches that could be used in clinical practice.-
dc.description.statementofresponsibilityJohan W. Mouton, Anouk E. Muller, Rafael Canton, Christian G. Giske, Gunnar Kahlmeter and John Turnidge-
dc.publisherOxford University Press-
dc.rights© The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email:
dc.subjectAnti-Bacterial Agents-
dc.subjectDrug Monitoring-
dc.subjectMicrobial Sensitivity Tests-
dc.subjectReproducibility of Results-
dc.subjectDose-Response Relationship, Drug-
dc.subjectBiological Variation, Population-
dc.titleMIC-based dose adjustment: facts and fables-
dc.typeJournal article-
dc.identifier.orcidTurnidge, J. [0000-0003-4240-5578]-
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