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https://hdl.handle.net/2440/116527
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dc.contributor.author | Direk, N. | - |
dc.contributor.author | Williams, S. | - |
dc.contributor.author | Smith, J. | - |
dc.contributor.author | Ripke, S. | - |
dc.contributor.author | Air, T. | - |
dc.contributor.author | Amare, A. | - |
dc.contributor.author | Amin, N. | - |
dc.contributor.author | Baune, B. | - |
dc.contributor.author | Bennett, D. | - |
dc.contributor.author | Blackwood, D. | - |
dc.contributor.author | Boomsma, D. | - |
dc.contributor.author | Breen, G. | - |
dc.contributor.author | Buttenschøn, H. | - |
dc.contributor.author | Byrne, E. | - |
dc.contributor.author | Børglum, A. | - |
dc.contributor.author | Castelao, E. | - |
dc.contributor.author | Cichon, S. | - |
dc.contributor.author | Clarke, T. | - |
dc.contributor.author | Cornelis, M. | - |
dc.contributor.author | Dannlowski, U. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Biological Psychiatry, 2017; 82(5):322-329 | - |
dc.identifier.issn | 0006-3223 | - |
dc.identifier.issn | 1873-2402 | - |
dc.identifier.uri | http://hdl.handle.net/2440/116527 | - |
dc.description.abstract | Background: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder. Methods: We analyzed two prior studies of 70,017 participants of European ancestry from general and clinical populations in the discovery stage. We performed a replication meta-analysis of 28,328 participants. Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were calculated using linkage disequilibrium score regression. Discovery and replication analyses were performed using a p-value-based meta-analysis. Lifetime major depressive disorder and depressive symptom scores were used as the outcome measures. Results: The SNP-based heritability of major depressive disorder was 0.21 (SE = 0.02), the SNP-based heritability of depressive symptoms was 0.04 (SE = 0.01), and their genetic correlation was 1.001 (SE = 0.2). We found one genome-wide significant locus related to the broad depression phenotype (rs9825823, chromosome 3: 61,082,153, p = 8.2 × 10–9) located in an intron of the FHIT gene. We replicated this SNP in independent samples (p = .02) and the overall meta-analysis of the discovery and replication cohorts (1.0 × 10–9). Conclusions: This large study identified a new locus for depression. Our results support a continuum between depressive symptoms and major depressive disorder. A phenotypically more inclusive approach may help to achieve the large sample sizes needed to detect susceptibility loci for depression. | - |
dc.description.statementofresponsibility | Nese Direk, Stephanie Williams, Jennifer A. Smith ... Tracy M. Air … Azmeraw T. Amare … Bernhard T. Baune ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Society of Biological Psychiatry | - |
dc.rights | © 2016 Society of Biological Psychiatry | - |
dc.source.uri | http://dx.doi.org/10.1016/j.biopsych.2016.11.013 | - |
dc.subject | CHARGE consortium | - |
dc.subject | Depressive symptoms | - |
dc.subject | FHIT gene | - |
dc.subject | Genome-wide association study | - |
dc.subject | Major depressive disorder | - |
dc.subject | Psychiatric Genomics Consortium | - |
dc.title | An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.biopsych.2016.11.013 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Air, T. [0000-0002-4834-4238] | - |
dc.identifier.orcid | Amare, A. [0000-0002-7940-0335] | - |
dc.identifier.orcid | Baune, B. [0000-0001-6548-426X] | - |
Appears in Collections: | Aurora harvest 8 Psychology publications |
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