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https://hdl.handle.net/2440/11667
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Type: | Journal article |
Title: | Fluconazole in the treatment of pulmonary zygomycosis |
Author: | Koszyca, B. Ellis, D. Toogood, I. Byard, R. |
Citation: | Mycoses: diagnosis, therapy and prophylaxis of fungal diseases, 1995; 38(7-8):277-280 |
Publisher: | Blackwell |
Issue Date: | 1995 |
ISSN: | 0933-7407 1439-0507 |
Abstract: | Pulmonary zygomycosis is an aggressive, often terminal infection that may be found in patients who are immunocompromised as a result of cytotoxic chemotherapy. Conventional treatment is by surgical debridement augmented with high-dose intravenous amphotericin B, but even with such treatment the course is usually fulminant with a high mortality rate. Recent work has suggested that the new antifungal triazole, fluconazole, may be of benefit in treating zygomycete infection. The case of a 15-year-old boy who developed pulmonary zygomycosis while on chemotherapy for acute lymphoblastic leukaemia, and who survived for 11 months with oral fluconazole therapy alone, is supportive of this proposal. |
Keywords: | Zygomycosis pulmonary mycosis acute lymphoblastic leukaemia fluconazole |
DOI: | 10.1111/j.1439-0507.1995.tb00407.x |
Published version: | http://dx.doi.org/10.1111/j.1439-0507.1995.tb00407.x |
Appears in Collections: | Aurora harvest 7 Microbiology and Immunology publications |
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