Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11667
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Type: Journal article
Title: Fluconazole in the treatment of pulmonary zygomycosis
Author: Koszyca, B.
Ellis, D.
Toogood, I.
Byard, R.
Citation: Mycoses, 1995; 38(7-8):277-280
Publisher: Blackwell
Issue Date: 1995
ISSN: 0933-7407
1439-0507
Abstract: Pulmonary zygomycosis is an aggressive, often terminal infection that may be found in patients who are immunocompromised as a result of cytotoxic chemotherapy. Conventional treatment is by surgical debridement augmented with high-dose intravenous amphotericin B, but even with such treatment the course is usually fulminant with a high mortality rate. Recent work has suggested that the new antifungal triazole, fluconazole, may be of benefit in treating zygomycete infection. The case of a 15-year-old boy who developed pulmonary zygomycosis while on chemotherapy for acute lymphoblastic leukaemia, and who survived for 11 months with oral fluconazole therapy alone, is supportive of this proposal.
Keywords: Zygomycosis; pulmonary mycosis; acute lymphoblastic leukaemia; fluconazole
RMID: 0030004162
DOI: 10.1111/j.1439-0507.1995.tb00407.x
Appears in Collections:Microbiology and Immunology publications

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