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|Title:||Fluconazole in the treatment of pulmonary zygomycosis|
|Citation:||Mycoses, 1995; 38(7-8):277-280|
|Abstract:||Pulmonary zygomycosis is an aggressive, often terminal infection that may be found in patients who are immunocompromised as a result of cytotoxic chemotherapy. Conventional treatment is by surgical debridement augmented with high-dose intravenous amphotericin B, but even with such treatment the course is usually fulminant with a high mortality rate. Recent work has suggested that the new antifungal triazole, fluconazole, may be of benefit in treating zygomycete infection. The case of a 15-year-old boy who developed pulmonary zygomycosis while on chemotherapy for acute lymphoblastic leukaemia, and who survived for 11 months with oral fluconazole therapy alone, is supportive of this proposal.|
|Keywords:||Zygomycosis; pulmonary mycosis; acute lymphoblastic leukaemia; fluconazole|
|Appears in Collections:||Microbiology and Immunology publications|
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