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dc.contributor.authorEscribà-Gelonch, M.-
dc.contributor.authorHessel, V.-
dc.contributor.authorMaier, M.-
dc.contributor.authorNoël, T.-
dc.contributor.authorNeira D'Angelo, M.-
dc.contributor.authorGruber-Woelfler, H.-
dc.identifier.citationOrganic Process Research and Development, 2018; 22(2):178-189-
dc.description.abstractA continuous tandem in-line evaporation–crystallization is presented. The process includes an in-line solvent-swap step, suitable to be coupled to a capillary based cooler. As a proof of concept, this setup is tested in a direct in-line acetonitrile mediated crystallization of Vitamin D₃. This configuration is suitable to be coupled to a new end-to-end continuous microflow synthesis of Vitamin D₃. By this procedure, vitamin particles can be crystallized in continuous flow and isolated using an in-line continuous filtration step. In one run in just 1 min of cooling time, ∼50% (w/w) crystals of Vitamin D₃ are directly obtained. Furthermore, the polymorphic form as well as crystals shape and size properties are described in this paper.-
dc.description.statementofresponsibilityMarc Escribà-Gelonch, Volker Hessel, Manuel C. Maier, Timothy Noël, Maria Fernanda Neira d’Angelo and Heidrun Gruber-Woelfler-
dc.publisherACS Publications-
dc.rights© 2017 American Chemical Society. ACS AuthorChoice - This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.-
dc.titleContinuous-flow in-line solvent-swap crystallization of vitamin D₃-
dc.title.alternativeContinuous-flow in-line solvent-swap crystallization of vitamin D(3)-
dc.typeJournal article-
dc.identifier.orcidHessel, V. [0000-0002-9494-1519]-
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