Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/116886
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dc.contributor.authorGhoreishifar, S.en
dc.contributor.authorMoradi-Shahrbabak, H.en
dc.contributor.authorMoradi-Shahrbabak, M.en
dc.contributor.authorNicolazzi, E.en
dc.contributor.authorWilliams, J.en
dc.contributor.authorIamartino, D.en
dc.contributor.authorNejati-Javaremi, A.en
dc.date.issued2018en
dc.identifier.citationLivestock Science, 2018; 216:174-182en
dc.identifier.issn1871-1413en
dc.identifier.issn1878-0490en
dc.identifier.urihttp://hdl.handle.net/2440/116886-
dc.description.abstractThe accuracy of genotype imputation from a customized low-density to a moderate-density single-nucleotide polymorphism marker panel was tested in Italian Mediterranean buffalo using different sizes of reference populations (RP) and imputation programs. Masked genotypes were imputed using Beagle, minimac and FImpute. The accuracy of predicted genotypes was assessed by the percentage of correctly imputed genotypes. As expected, overall imputation accuracy was better for larger RP sizes. However, increasing the RP size from small to intermediate (i.e., from 42 to 202) resulted in a greater improvement in imputation accuracy compared to increasing the RP size from intermediate to large (i.e., from 202 to 736). The percentage of correctly imputed genotypes was 97.3%, 97.9% and 98.0% for minimac, Beagle and FImpute, respectively, using 736 reference individuals. The accuracy of imputation tended to decrease for high minor-allele frequency of imputed genotypes especially when the RP size was small. The variation in accuracy with increasing RP size was highest for Beagle and lowest for minimac. The accuracy of imputation was larger when the genomic relationship between the reference and the target populations was higher for all three imputation software tools used in this study. The trend of increasing imputation accuracy with genomic relationship was strongest when the RP size was small. Our results indicate that imputation of genotypes from a low to a moderate density panel (i.e., 10K to 90K) is a valid option to reduce the cost of genotyping for genomic evaluation in Italian Mediterranean buffalo.en
dc.description.statementofresponsibilitySeyed Mohammad Ghoreishifar, Hossein Moradi-Shahrbabak, Mohammad Moradi-Shahrbabak, Ezequiel L.Nicolazzi, John L.Williams, Daniela Iamartino, Ardeshir Nejati-Javaremien
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2018 Elsevier B.V. All rights reserved.en
dc.subjectImputation accuracy; reference population size; imputation programs; Italian mediterranean buffalo; single-nucleotide polymorphismen
dc.titleAccuracy of imputation of single-nucleotide polymorphism marker genotypes for water buffaloes (Bubalus bubalis) using different reference population sizes and imputation toolsen
dc.typeJournal articleen
dc.identifier.rmid0030099491en
dc.identifier.doi10.1016/j.livsci.2018.08.009en
dc.identifier.pubid436229-
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWilliams, J. [0000-0001-5188-7957]en
Appears in Collections:Animal and Veterinary Sciences publications

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