Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMalbert, C.-
dc.contributor.authorPicq, C.-
dc.contributor.authorDivoux, J.-
dc.contributor.authorHenry, C.-
dc.contributor.authorHorowitz, M.-
dc.identifier.citationDiabetes, 2017; 66(4):848-857-
dc.description.abstractAcute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral vagal stimulation is not known. Our aim was to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after permanent, bilateral, vagal stimulation performed at the abdominal level in adult mini-pigs. In 15 adult mini-pigs, stimulating electrodes were placed around the dorsal and ventral vagi using laparoscopy and connected to a dual-channel stimulator placed subcutaneously. Animals were divided into three groups based on stimulation and body weight (i.e., lean nonstimulated, obese nonstimulated, and obese stimulated). Twelve weeks after surgery, glucose uptake and insulin sensitivity were measured using positron emission tomography during an isoglycemic clamp. Mean whole-body insulin sensitivity was lower by 34% (P < 0.01) and the hepatic glucose uptake rate was lower by 33% (P < 0.01) in obese-nonstimulated mini-pigs but was no different in obese-stimulated compared with lean mini-pigs. An improvement in skeletal glucose uptake rate was also observed in obese-stimulated compared with obese-nonstimulated groups (P < 0.01). Vagal stimulation was associated with increased glucose metabolism in the cingulate and prefrontal brain areas. We conclude that chronic vagal stimulation improves insulin sensitivity substantially in diet-induced obesity by both peripheral and central mechanisms.-
dc.description.statementofresponsibilityCharles-Henri Malbert, Chloé Picq, Jean-Louis Divoux, Christine Henry and Michael Horowitz-
dc.publisherAmerican Diabetes Association-
dc.rights© 2017 by the American Diabetes Association.-
dc.subjectMuscle, Skeletal-
dc.titleObesity-Associated alterations in glucose metabolism are reversed by chronic bilateral stimulation of the abdominal vagus nerve-
dc.typeJournal article-
dc.identifier.orcidMalbert, C. [0000-0002-0665-4545]-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
Appears in Collections:Aurora harvest 8
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.