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https://hdl.handle.net/2440/11700
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dc.contributor.author | Lok, F. | - |
dc.contributor.author | Owens, J. | - |
dc.contributor.author | Mundy, L. | - |
dc.contributor.author | Robinson, J. | - |
dc.contributor.author | Owens, P. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | American Journal of Physiology, 1996; 270(5):R1148-R1155 | - |
dc.identifier.issn | 0002-9513 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11700 | - |
dc.description.abstract | Insulin-like growth factor I (IGF-I) is required for normal fetal growth and skeletal maturation in late gestation, because null mutations of the IGF-I gene in mice reduce fetal weight and retard ossification of bones. To determine if, conversely, increased abundance of IGF-I promotes fetal growth and skeletal maturation, fetal sheep were infused intravascularly with recombinant human IGF-I (n = 7) (26 +/- 3 micrograms. h-1.kg-1) from 120 to 130 days gestation and compared with controls (n = 15). IGF-I infusion increased plasma IGF-I concentrations by 140% (P = 0.002) and weights of fetal liver, lungs, heart, kidneys, spleen, pituitary, and adrenal glands by 16-50% (P < 0.05). Weights and/or lengths of the fetus, placenta, gastrointestinal tract, individual skeletal muscles, and long bones were unchanged by IGF-I. However, IGF-I increased the percentage of proximal epiphyses of long bones present (P < 0.05) and their cross-sectional areas by 15 to 38% (P < 0.05). These results show that IGF-I promotes growth of major fetal organs, endocrine glands, and skeletal maturation in vivo, consistent with IGF-I actively controlling and not merely facilitating fetal growth. The variable response of different tissues may partly reflect tissue specificity in growth requirements for additional factors. | - |
dc.description.statementofresponsibility | Fong Lok, Julie A. Owens, Linda Mundy, Jeffrey S. Robinson, and Phillip C. Owens | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | Copyright © 1996 the American Physiological Society | - |
dc.source.uri | http://ajpregu.physiology.org/content/270/5/R1148 | - |
dc.subject | Musculoskeletal System | - |
dc.subject | Fetal Blood | - |
dc.subject | Fetus | - |
dc.subject | Placenta | - |
dc.subject | Animals | - |
dc.subject | Sheep | - |
dc.subject | Humans | - |
dc.subject | Insulin | - |
dc.subject | Insulin-Like Growth Factor I | - |
dc.subject | Insulin-Like Growth Factor II | - |
dc.subject | Recombinant Proteins | - |
dc.subject | Embryonic and Fetal Development | - |
dc.subject | Bone Development | - |
dc.subject | Pregnancy | - |
dc.subject | Female | - |
dc.title | Insulin-like growth factor-I promotes growth selectively in fetal sheep in late gestation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.1996.270.5.r1148 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
dc.identifier.orcid | Mundy, L. [0000-0002-7874-4232] | - |
dc.identifier.orcid | Robinson, J. [0000-0002-4515-6039] | - |
Appears in Collections: | Aurora harvest 7 Physiology publications |
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