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https://hdl.handle.net/2440/11702
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DC Field | Value | Language |
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dc.contributor.author | Sohlstrom, A. | - |
dc.contributor.author | Katsman, A. | - |
dc.contributor.author | Kind, K. | - |
dc.contributor.author | Roberts, C. | - |
dc.contributor.author | Owens, P. | - |
dc.contributor.author | Robinson, J. | - |
dc.contributor.author | Owens, J. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | American Journal of Physiology: Endocrinology and Metabolism, 1998; 274(37):E410-E416 | - |
dc.identifier.issn | 0193-1849 | - |
dc.identifier.issn | 2163-5773 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11702 | - |
dc.description.abstract | The effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother. | - |
dc.language.iso | en | - |
dc.publisher | AMER PHYSIOLOGICAL SOC | - |
dc.rights | © 1998 the American Physiological Society | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpendo.1998.274.3.e410 | - |
dc.subject | Animals | - |
dc.subject | Guinea Pigs | - |
dc.subject | Weight Gain | - |
dc.subject | Insulin-Like Growth Factor I | - |
dc.subject | Insulin-Like Growth Factor II | - |
dc.subject | Insulin-Like Growth Factor Binding Proteins | - |
dc.subject | Insulin-Like Growth Factor Binding Protein 1 | - |
dc.subject | Insulin-Like Growth Factor Binding Protein 2 | - |
dc.subject | Insulin-Like Growth Factor Binding Protein 3 | - |
dc.subject | Insulin-Like Growth Factor Binding Protein 4 | - |
dc.subject | Food Deprivation | - |
dc.subject | Body Composition | - |
dc.subject | Embryonic and Fetal Development | - |
dc.subject | Pregnancy | - |
dc.subject | Placentation | - |
dc.subject | Pregnancy, Animal | - |
dc.subject | Female | - |
dc.title | Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpendo.1998.274.3.e410 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Roberts, C. [0000-0002-9250-2192] | - |
dc.identifier.orcid | Robinson, J. [0000-0002-4515-6039] | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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