Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/11702
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSohlstrom, A.-
dc.contributor.authorKatsman, A.-
dc.contributor.authorKind, K.-
dc.contributor.authorRoberts, C.-
dc.contributor.authorOwens, P.-
dc.contributor.authorRobinson, J.-
dc.contributor.authorOwens, J.-
dc.date.issued1998-
dc.identifier.citationAmerican Journal of Physiology: Endocrinology and Metabolism, 1998; 274(37):E410-E416-
dc.identifier.issn0193-1849-
dc.identifier.issn2163-5773-
dc.identifier.urihttp://hdl.handle.net/2440/11702-
dc.description.abstractThe effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother.-
dc.language.isoen-
dc.publisherAMER PHYSIOLOGICAL SOC-
dc.rights© 1998 the American Physiological Society-
dc.source.urihttp://dx.doi.org/10.1152/ajpendo.1998.274.3.e410-
dc.subjectAnimals-
dc.subjectGuinea Pigs-
dc.subjectWeight Gain-
dc.subjectInsulin-Like Growth Factor I-
dc.subjectInsulin-Like Growth Factor II-
dc.subjectInsulin-Like Growth Factor Binding Proteins-
dc.subjectInsulin-Like Growth Factor Binding Protein 1-
dc.subjectInsulin-Like Growth Factor Binding Protein 2-
dc.subjectInsulin-Like Growth Factor Binding Protein 3-
dc.subjectInsulin-Like Growth Factor Binding Protein 4-
dc.subjectFood Deprivation-
dc.subjectBody Composition-
dc.subjectEmbryonic and Fetal Development-
dc.subjectPregnancy-
dc.subjectPlacentation-
dc.subjectPregnancy, Animal-
dc.subjectFemale-
dc.titleFood restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig-
dc.typeJournal article-
dc.identifier.doi10.1152/ajpendo.1998.274.3.e410-
pubs.publication-statusPublished-
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]-
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]-
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]-
Appears in Collections:Aurora harvest 2
Physiology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.