Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117073
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Type: Journal article
Title: Historical evolution of ideas on eclampsia/preeclampsia: a proposed optimistic view of preeclampsia
Author: Robillard, P.-Y.
Dekker, G.
Chaouat, G.
Scioscia, M.
Iacobelli, S.
Hulsey, T.C.
Citation: Journal of Reproductive Immunology, 2017; 123:72-77
Publisher: Elsevier
Issue Date: 2017
ISSN: 0165-0378
1872-7603
Statement of
Responsibility: 
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Silvia Iacobelli, Thomas C. Hulsey
Abstract: Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease. The "paternity problem" (and therefore irruption of immunology), 5) at the end of the 1980's, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral endotheliosis, HELLP, eclampsia), inflammation (J.Roberts.C Redman, R Taylor), 6) End of the 1990's: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34 weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etc…). LOP is predominant everywhere on this planet, but enormously predominant in developed countries: 90% of cases. This feature is very different in countries where women have their first child very young (88% of world births), where the fatal EOP (early onset) occurs in more than 30% of cases. 7) What could be the common factor which could explain the maternal global endotheliosis in EOP and LOP? Discussion about the inositol phospho glycans P type.
Keywords: Preeclampsia; immunology
Rights: © 2017 Published by Elsevier Ireland Ltd.
DOI: 10.1016/j.jri.2017.09.006
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