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dc.contributor.authorRobillard, P.-Y.-
dc.contributor.authorDekker, G.-
dc.contributor.authorChaouat, G.-
dc.contributor.authorScioscia, M.-
dc.contributor.authorIacobelli, S.-
dc.contributor.authorHulsey, T.C.-
dc.identifier.citationJournal of Reproductive Immunology, 2017; 123:72-77-
dc.description.abstractEclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease. The "paternity problem" (and therefore irruption of immunology), 5) at the end of the 1980's, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral endotheliosis, HELLP, eclampsia), inflammation (J.Roberts.C Redman, R Taylor), 6) End of the 1990's: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34 weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etc…). LOP is predominant everywhere on this planet, but enormously predominant in developed countries: 90% of cases. This feature is very different in countries where women have their first child very young (88% of world births), where the fatal EOP (early onset) occurs in more than 30% of cases. 7) What could be the common factor which could explain the maternal global endotheliosis in EOP and LOP? Discussion about the inositol phospho glycans P type.-
dc.description.statementofresponsibilityPierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Silvia Iacobelli, Thomas C. Hulsey-
dc.rights© 2017 Published by Elsevier Ireland Ltd.-
dc.subjectPreeclampsia; immunology-
dc.titleHistorical evolution of ideas on eclampsia/preeclampsia: a proposed optimistic view of preeclampsia-
dc.typeJournal article-
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]-
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