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https://hdl.handle.net/2440/117154
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Type: | Journal article |
Title: | Bone marrow myeloid cells regulate myeloid-biased hematopoietic stem cells via a histamine-dependent feedback loop |
Author: | Chen, X. Deng, H. Churchill, M. Luchsinger, L. Du, X. Chu, T. Friedman, R. Middelhoff, M. Ding, H. Tailor, Y. Wang, A. Liu, H. Niu, Z. Wang, H. Jiang, Z. Renders, S. Ho, S. Shah, S. Tishchenko, P. Chang, W. et al. |
Citation: | Cell Stem Cell, 2017; 21(6):747-760 |
Publisher: | Elsevier |
Issue Date: | 2017 |
ISSN: | 1934-5909 1875-9777 |
Statement of Responsibility: | Xiaowei Chen ... Daniel L. Worthley ... et al. |
Abstract: | Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc). Committed Hdc⁺ myeloid cells lie in close anatomical proximity to MB-HSCs and produce histamine, which activates the H₂ receptor on MB-HSCs to promote their quiescence and self-renewal. Depleting histamine-producing cells enforces cell cycle entry, induces loss of serial transplant capacity, and sensitizes animals to chemotherapeutic injury. Increasing demand for myeloid cells via lipopolysaccharide (LPS) treatment specifically recruits MB-HSCs and progenitors into the cell cycle; cycling MB-HSCs fail to revert into quiescence in the absence of histamine feedback, leading to their depletion, while an H₂ agonist protects MB-HSCs from depletion after sepsis. Thus, histamine couples lineage-specific physiological demands to intrinsically primed MB-HSCs to enforce homeostasis. |
Keywords: | H2 receptor; bone marrow niche; hematopoietic stem cells; histamine; myeloid biased |
Rights: | Copyright status unknown |
DOI: | 10.1016/j.stem.2017.11.003 |
Published version: | http://dx.doi.org/10.1016/j.stem.2017.11.003 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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