Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117185
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Type: Journal article
Title: Baseline and treatment-related changes in thrombin generation in patients with multiple myeloma
Author: Tiong, I.
Rodgers, S.
Lee, C.
McRae, S.
Citation: Leukemia and Lymphoma, 2017; 58(4):941-949
Publisher: Taylor & Francis
Issue Date: 2017
ISSN: 1042-8194
1029-2403
Statement of
Responsibility: 
Ing S. Tiong, Susan E. Rodgers, Cindy H.S. Lee and Simon J. McRae
Abstract: The prothrombotic risk in multiple myeloma (MM) could be potentially assessed by thrombin generation (TG) assays. TG was performed using Calibrated Automated Thrombography with 5 and 1 pM tissue factor. We compared baseline TG among 24 MM patients, 19 MGUS, and 50 healthy controls, and assessed change in TG in MM patients during the initial treatment period at 1, 2, and 3 months. MM subjects demonstrated increased FVIII and VWF:Ag levels pretreatment, and a prothrombotic TG phenotype with increased velocity index, reduced lag time and time-to-peak, and increased resistance to thrombomodulin inhibition. There were no significant changes in TG with treatment for the majority of parameters, however, MM subjects exhibited persistent elevation of velocity index throughout treatment. Two subjects developed thrombosis during the study period despite thromboprophylaxis. This study provides information on the optimal conditions for examining TG as a predictor of thrombotic risk in MM patients.
Keywords: Monoclonal gammopathy; multiple myeloma; thrombin generation; venous thromboembolism; hypercoagulability
Rights: © 2016 Informa UK Limited, trading as Taylor & Francis Group
DOI: 10.1080/10428194.2016.1219900
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