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|Title:||Macrocyclic peptidomimetics prepared by ring-closing metathesis and azide-alkyne cycloaddition|
|Citation:||Australian Journal of Chemistry: an international journal for chemical science, 2017; 70(2):138-151|
|Ashok D. Pehere, Xiaozhou Zhang, and Andrew D. Abell|
|Abstract:||Macrocycles are finding increasing use as a means to define the backbone geometries of peptides and peptidomimetics. Ring-closing metathesis and CuI-catalyzed azide–alkyne cycloaddition are particularly useful for introducing such rings and they do so in high yield and with a good functional group tolerance and compatibility. Here, we present an overview of the use of these two methods, with reference to selected examples and particular reference to b-strand peptidomimetics for use as protease inhibitors.|
|Rights:||© CSIRO 2017|
|Appears in Collections:||Aurora harvest 3|
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