Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117226
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Type: Journal article
Title: Macrocyclic peptidomimetics prepared by ring-closing metathesis and azide-alkyne cycloaddition
Author: Pehere, A.
Zhang, X.
Abell, A.
Citation: Australian Journal of Chemistry: an international journal for chemical science, 2017; 70(2):138-151
Publisher: CSIRO Publishing
Issue Date: 2017
ISSN: 0004-9425
1445-0038
Statement of
Responsibility: 
Ashok D. Pehere, Xiaozhou Zhang, and Andrew D. Abell
Abstract: Macrocycles are finding increasing use as a means to define the backbone geometries of peptides and peptidomimetics. Ring-closing metathesis and CuI-catalyzed azide–alkyne cycloaddition are particularly useful for introducing such rings and they do so in high yield and with a good functional group tolerance and compatibility. Here, we present an overview of the use of these two methods, with reference to selected examples and particular reference to b-strand peptidomimetics for use as protease inhibitors.
Rights: © CSIRO 2017
DOI: 10.1071/CH16532
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