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https://hdl.handle.net/2440/117226
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Type: | Journal article |
Title: | Macrocyclic peptidomimetics prepared by ring-closing metathesis and azide-alkyne cycloaddition |
Author: | Pehere, A.D. Zhang, X. Abell, A.D. |
Citation: | Australian Journal of Chemistry: an international journal for chemical science, 2017; 70(2):138-151 |
Publisher: | CSIRO Publishing |
Issue Date: | 2017 |
ISSN: | 0004-9425 1445-0038 |
Statement of Responsibility: | Ashok D. Pehere, Xiaozhou Zhang, and Andrew D. Abell |
Abstract: | Macrocycles are finding increasing use as a means to define the backbone geometries of peptides and peptidomimetics. Ring-closing metathesis and CuI-catalyzed azide–alkyne cycloaddition are particularly useful for introducing such rings and they do so in high yield and with a good functional group tolerance and compatibility. Here, we present an overview of the use of these two methods, with reference to selected examples and particular reference to b-strand peptidomimetics for use as protease inhibitors. |
Rights: | © CSIRO 2017 |
DOI: | 10.1071/CH16532 |
Published version: | http://dx.doi.org/10.1071/ch16532 |
Appears in Collections: | Aurora harvest 3 IPAS publications |
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