Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117356
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?
Author: Tan, L.Y.
Martini, C.
Fridlender, Z.G.
Bonder, C.S.
Brown, M.P.
Ebert, L.M.
Citation: Clinical and Translational Immunology, 2017; 6(3):e134-1-e134-9
Publisher: Wiley
Issue Date: 2017
ISSN: 2050-0068
2050-0068
Statement of
Responsibility: 
Lih Yin Tan, Carmela Martini, Zvi G Fridlender, Claudine S Bonder, Michael P Brown and Lisa M Ebert
Abstract: Metastatic melanoma remains a fatal disease to many worldwide, even after the breakthrough introduction of targeted therapies such as BRAF inhibitors and immune checkpoint blockade therapies such as CTLA-4 and PD-1 inhibitors. With advances in our understanding of this disease, as well as the increasing data gathered from patient studies, the significance of the host immune response to cancer progression and response to treatment is becoming clear. More specifically, the presence of intratumoral CD8⁺ cytotoxic T-cells correlates with better prognosis whereas the accumulation of monocytes/macrophages and neutrophils in the tumour is often associated with worse prognosis. Access and infiltration of circulating leukocytes into the tumour is governed by adhesion molecules and chemokines expressed by the endothelial cells of the vasculature. This review focuses on the adhesion molecules and chemokines which control the homing of CD8⁺ cytotoxic T-cells, monocytes and neutrophils to peripheral tissues, including tumours. We discuss the role of these leukocyte subsets in regulating melanoma growth, and detail the mechanisms used by tumours to selectively recruit or exclude these leukocytes for their own advantage. In doing so, we bring to light an underappreciated component of tumour biology which should be considered in combination with current treatments to selectively alter the leukocyte composition of tumours and ultimately enhance treatment outcome.
Rights: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
RMID: 0030083568
DOI: 10.1038/cti.2017.7
Appears in Collections:Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_117356.pdfPublished version488.84 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.