Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Daytime loop gain is elevated in obstructive sleep apnea but not reduced by CPAP treatment|
|Citation:||Journal of Applied Physiology, 2018; 125(5):1490-1497|
|Publisher:||American Physiological Society|
|Naomi Louise Deacon-Diaz, Scott A. Sands, R. Doug McEvoy and Peter G. Catcheside|
|Abstract:||Reduced ventilatory control stability (elevated loop gain) is a key non-anatomical pathological trait contributing to obstructive sleep apnea (OSA), yet the mechanisms responsible remain unclear. We sought to identify the key factors contributing to elevated loop gain in OSA (controller versus plant contributions) and to examine if abnormalities in these factors persist after OSA treatment. In 15 males (8 OSA, 7 height, weight- and age-matched controls) we measured loop gain, controller gain and plant gain using a pseudorandom binary CO₂ stimulation method during wakefulness. Factors potentially influencing plant gain were also assessed (supine lung volume via helium dilution and spirometry). Measures were repeated 2 and 6 weeks after initiating CPAP. Loop gain was higher in OSA versus controls (LG at 1 cycle/min 0.28 ± 0.04 versus 0.16 ± 0.04, p = 0.046) and the controller exhibited a greater peak response to CO2 and faster roll-off in OSA. OSA patients also exhibited reduced FEV1 and FVC compared to controls (92.2 ± 1.7 versus 102.9 ± 3.5% predicted, p = 0.021; 93.4 ± 3.1 versus 106.6 ± 3.6% predicted, p = 0.015, respectively). There was no effect of treatment on any variable. These findings confirm loop gain is higher in untreated OSA patients than in matched controls, however this was not affected by treatment.|
|Keywords:||Continuous positive airway pressure; loop gain; obstructive sleep apnea|
|Rights:||Copyright © 2018 the American Physiological Society|
|Appears in Collections:||Aurora harvest 3|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.