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Type: Journal article
Title: Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity
Author: Pearce, K.
Hatzinikolas, A.
Moran, L.
de Courten, M.P.J.
Forbes, J.
Scheijen, J.L.J.M.
Schalkwijk, C.J.
Walker, K.
de Courten, B.
Citation: International Journal of Food Sciences and Nutrition, 2017; 68(8):1021-1026
Publisher: Taylor & Francis
Issue Date: 2017
ISSN: 0963-7486
Statement of
Karma Pearce, Alicia Hatzinikolas, Lisa Moran, Maximilian P. J. de Courten, Josephine Forbes, Jean L. J. M. Scheijen, Casper G. Schalkwijk, Karen Walker and Barbora de Courten
Abstract: We have previously shown that an isoenergetic low advanced glycation end products (AGEs) diet matched for macronutrient content improved insulin sensitivity compared to high AGE diet. Here, we evaluated the differences in micronutrient intake of these two dietary patterns and if they could explain differences in insulin sensitivity. Participants consumed the intervention diets each for 2 weeks with 4 weeks of habitual dietary intake (washout) in-between. Dietary analysis revealed that the high AGE diet contained greater levels of retinol equivalents (RE) (478.9 + 151.3 μg/day versus 329.0 + 170.0 μg/day; p < .006), vitamin A (806.3 + 223.5 (μg RE)/day versus 649.1 + 235.8 (μg RE)/day; p < .05) and thiamine (2.3 + 0.6 mg/day versus 1.6 + 0.4 mg/day; p = .014) compared to the low AGE diet. The changes in polyunsaturated fat, retinol, vitamin A and thiamine did not correlate with changes in insulin sensitivity (all p > .1) therefore are unlikely to explain observed changes in insulin sensitivity.
Keywords: Advanced glycation end products (AGEs); ageing; chronic disease; lifestyle disease
Rights: © 2017 Informa UK Limited, trading as Taylor & Francis Group
DOI: 10.1080/09637486.2017.1319468
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