Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117405
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Type: Journal article
Title: Dynamic analyses of osteoblast vibrational responses: a finite element viscoelastic model
Author: Wang, L.
Xian, C.J.
Citation: Journal of Vibroengineering, 2016; 18(7):4605-4616
Publisher: JVE International
Issue Date: 2016
ISSN: 1392-8716
2538-8460
Statement of
Responsibility: 
Liping Wang, Cory J. Xian
Abstract: Mechanotransduction is an important process that influences bone remodeling and maintains viability of bone cells. To understand the effect of the vibrational mechanical stimulation on biomechanic responses of bone cells, a viscoelastic osteoblast finite element (FE) model was developed. Firstly, the mode shapes and natural frequencies of a spreading osteoblast were assessed using the FE modal analysis. The osteoblast FE model predicted the natural frequencies of osteoblasts (within the range about 19.99-34.48 Hz). Then, the effect of acceleration on the vibrational responses of in-vitro cultured osteoblasts was investigated. Three different accelerations of base excitation were selected (0.15g, 0.3g and 0.5g, where g = 9.8 m/s²) and the vibrational responses (displacement, strain and stress) of osteoblasts were simulated. It was found that values of displacement, strain and stress increase with the increase of base excitation acceleration. In addition, the response values in Z-direction are much higher than those in the other directions (X, Y-direction) for the same base excitation acceleration. These findings will provide useful information to understand how vibrational mechanical stimulus influences bone cells and provide guidance for in vitro cell culture and experimental research and ultimately clinical treatment using the external vibrating loading.
Keywords: Vibration modes; natural frequency; modal analysis; finite element analysis; osteoblast
Rights: Copyright © 2016 JVE International Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.21595/jve.2016.17211
Grant ID: NHMRC
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