Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117484
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTucci, S.en
dc.contributor.authorVohr, S.en
dc.contributor.authorMcCoy, R.en
dc.contributor.authorVernot, B.en
dc.contributor.authorRobinson, M.en
dc.contributor.authorBarbieri, C.en
dc.contributor.authorNelson, B.en
dc.contributor.authorFu, W.en
dc.contributor.authorPurnomo, G.en
dc.contributor.authorSudoyo, H.en
dc.contributor.authorEichler, E.en
dc.contributor.authorBarbujani, G.en
dc.contributor.authorVisscher, P.en
dc.contributor.authorAkey, J.en
dc.contributor.authorGreen, R.en
dc.date.issued2018en
dc.identifier.citationScience, 2018; 361(6401):511-516en
dc.identifier.issn0036-8075en
dc.identifier.issn1095-9203en
dc.identifier.urihttp://hdl.handle.net/2440/117484-
dc.description.abstractFlores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.en
dc.description.statementofresponsibilitySerena Tucci, Samuel H. Vohr, Rajiv C. McCoy, Benjamin Vernot, Matthew R. Robinson, Chiara Barbieri, Brad J. Nelson, Wenqing Fu, Gludhug A. Purnomo, Herawati Sudoyo, Evan E. Eichler, Guido Barbujani, Peter M. Visscher, Joshua M. Akey, Richard E. Greenen
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.rights2017 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. The title Science is a registered trademark of AAAS.en
dc.subjectHomo floresiensis; evolutionary historyen
dc.titleEvolutionary history and adaptation of a human pygmy population of Flores Island, Indonesiaen
dc.typeJournal articleen
dc.identifier.rmid0030098162en
dc.identifier.doi10.1126/science.aar8486en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP160102400en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1078037en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1113400en
dc.identifier.pubid438225-
pubs.library.collectionGenetics publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidPurnomo, G. [0000-0001-7616-5977]en
Appears in Collections:Genetics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.