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Type: Journal article
Title: Silver nanoparticle modified surfaces induce differentiation of mouse kidney-derived stem cells
Author: Roy Chowdhury, N.
Hopp, I.
Zilm, P.
Murray, P.
Vasilev, K.
Citation: RSC Advances, 2018; 8(36):20334-20340
Publisher: Royal Society of Chemistry
Issue Date: 2018
ISSN: 2046-2069
Statement of
Neelika Roy Chowdhury, Isabel Hopp, Peter Zilm, Patricia Murray and Krasimir Vasilev
Abstract: In this paper, we interrogate the influence of silver nanoparticle (AgNPs)-based model surfaces on mouse kidney-derived stem cells (mKSCs) differentiation. The widespread use of silver in biomedical and consumer products requires understanding of this element's effect on kidney cells. Moreover, the potential for using stem cells in drug discovery require methods to direct their differentiation to specialized cells. Hence, we generated coated model substrates containing different concentrations of surface immobilized AgNPs, and used them to evaluate properties and functions of mKSCs. Initially, mKSCs exhibited reduced viability on higher silver containing surfaces. However, longer culture periods assisted mKSCs to recover. Greater degree of cell spreading and arborization led by AgNPs, suggest podocyte differentiation. Proximal tubule cell marker's expression revealed differentiation to the specific lineage. Although the exact mechanism underpinning these findings require significant future efforts, this study demonstrate silver's capacity to stimulate mKSC differentiation, which may provide opportunities for drug screenings.
Rights: This journal is © The Royal Society of Chemistry 2018. Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
RMID: 0030099486
DOI: 10.1039/c8ra02145g
Grant ID:
Appears in Collections:Dentistry publications

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