Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117569
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Type: Journal article
Title: Induction of neutralizing antibody response against koala retrovirus (KoRV) and reduction in viral load in koalas following vaccination with recombinant KoRV envelope protein
Author: Olagoke, O.
Miller, D.
Hemmatzadeh, F.
Stephenson, T.
Fabijan, J.
Hutt, P.
Finch, S.
Speight, N.
Timms, P.
Citation: npj Vaccines, 2018; 3(1):30-1-30-8
Publisher: Nature Research (part of Springer Nature)
Issue Date: 2018
ISSN: 2059-0105
2059-0105
Statement of
Responsibility: 
O Olagoke, D Miller, F Hemmatzadeh, T Stephenson, J Fabijan, P Hutt, S Finch, N Speight and P Timms
Abstract: Koala retrovirus (KoRV) infects the majority of Australia's koalas (Phascolarctos cinereus) and has been linked to several life-threatening diseases such as lymphoma and leukemia, as well as Chlamydia and thus poses a threat to the continued survival of this species. While quarantine and antiretroviral drug treatment are possible control measures, they are impractical, leaving vaccination as the only realistic option. In this study, we examined the effect of a recombinant envelope protein-based anti-KoRV vaccine in two groups of South Australian koalas: KoRV infected or KoRV free. We report a successful vaccination response in the koalas with no vaccine-associated side effects. The vaccine induced a significant humoral immune response as well as the production of neutralizing antibodies in both groups of koalas. We also identified B-cell epitopes that were differentially recognized in KoRV-infected versus KoRV-free koalas following vaccination. Importantly, we also showed that vaccination had a therapeutic effect on koalas infected exogenously with KoRV by reducing their circulating viral load. Together, this study highlights the possibility of successfully developing a vaccine against KoRV infection in koalas.
Rights: © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI: 10.1038/s41541-018-0066-4
Grant ID: http://purl.org/au-research/grants/arc/LP150100046
Appears in Collections:Animal and Veterinary Sciences publications
Aurora harvest 8

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