Please use this identifier to cite or link to this item:
http://hdl.handle.net/2440/117628
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Evolution of the oral microbiome and dental caries |
Author: | Adler, C. Browne, G. Sukumar, S. Hughes, T. |
Citation: | Current Oral Health Reports, 2017; 4(3):264-269 |
Publisher: | Springer |
Issue Date: | 2017 |
ISSN: | 2196-3002 2196-3002 |
Statement of Responsibility: | Christina J Adler, Gina V Browne, Smitha Sukumar, Toby Hughes |
Abstract: | Purpose of our review Our paper reviews how dietary changes during human evolution have contributed to the increased incidence and prevalence of dental caries in modern populations by shifting the oral microbiome from a “healthy” to “carious” state. We addressed two questions: (1) what is the microbial difference between the states of health and caries, and (2) how has the development of an agricultural diet impacted the oral microbiome? RECENT FINDINGS The application of next-generation sequencing has revealed the complexity of the oral microbiome and lack of a simple compositional difference between health and caries. Genetic analysis of the oral microbiome from contemporary and ancient humans has shown that the introduction of agriculture was associated with increased frequency of caries-related bacteria and the evolution of the key carious pathogen, Streptococcus mutans. SUMMARY The adoption of an agricultural diet has contributed to a modern rise in caries by changing the oral microbiome ecology. Identification of evolutionary factors that have influenced the oral microbiome in health and caries, and how the two states differ functionally, as opposed to compositionally, may help to reduce the current burden of caries. |
Keywords: | Oral microbiome; dental caries; evolution; diet; agriculture; hunter-gatherer |
Rights: | © Springer International Publishing AG 2017 |
RMID: | 0030075021 |
DOI: | 10.1007/s40496-017-0151-1 |
Appears in Collections: | Dentistry publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_117628.pdf | Submitted version | 655.8 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.