Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117661
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The role of metabotropic glutamate receptors in addiction: evidence from preclinical models
Author: Duncan, J.
Lawrence, A.
Citation: Pharmacology Biochemistry and Behavior, 2012; 100(4):811-824
Publisher: Elsevier
Issue Date: 2012
ISSN: 0091-3057
1873-5177
Statement of
Responsibility: 
Jhodie R.Duncan, Andrew J.Lawrence
Abstract: Addiction is a chronic disorder characterised by repeated bouts of drug taking, abstinence and relapse. The addicted state may be in part due to drug-induced neuroadaptations in the mesocorticolimbic and corticostriatal pathways. Recently focus has been on the role of aberrant glutamate transmission and its contribution to the hierarchical control over these systems. This review will expand our current knowledge of the most recent advances that have been made in preclinical animal models that provide evidence that implicate metabotropic glutamate receptors (mGluRs) in contributing to the neuroadaptations pertinent to addiction, as well as the role of Homer proteins in regulating these responses. The recent discovery of receptor mosaics will be discussed which add an additional dimension to the complexity of understanding the mechanism of glutamate mediated behaviours. Finally this review introduces a new area related to glutamatergic responses, namely microRNAs, that may become pivotal in directing our future understanding of how to best target intervention strategies to prevent addictive behaviours.
Keywords: Addiction; synaptic plasticity; memory; learning; extinction training; calcium; microRNA; Homer
Rights: © 2011 Elsevier Inc. All rights reserved.
RMID: 0030101762
DOI: 10.1016/j.pbb.2011.03.015
Grant ID: http://purl.org/au-research/grants/nhmrc/566736
http://purl.org/au-research/grants/nhmrc/454303
http://purl.org/au-research/grants/arc/FT100100235
Appears in Collections:Medical Sciences publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.