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Type: Journal article
Title: Molecular causes of aneuploidy in mammalian eggs
Author: Jones, K.T.
Lane, S.I.R.
Citation: Development (Cambridge), 2013; 140(18):3719-3730
Publisher: The Company of Biologists Ltd
Issue Date: 2013
ISSN: 0950-1991
Statement of
Keith T. Jones and Simon I. R. Lane
Abstract: Mammalian oocytes are particularly error prone in segregating their chromosomes during their two meiotic divisions. This results in the creation of an embryo that has inherited the wrong number of chromosomes: it is aneuploid. The incidence of aneuploidy rises significantly with maternal age and so there is much interest in understanding this association and the underlying causes of aneuploidy. The spindle assembly checkpoint, a surveillance mechanism that operates in all cells to prevent chromosome mis-segregation, and the cohesive ties that hold those chromosomes together, have thus both been the subject of intensive investigation in oocytes. It is possible that a lowered sensitivity of the spindle assembly checkpoint to certain types of chromosome attachment error may endow oocytes with an innate susceptibility to aneuploidy, which is made worse by an age-related loss in the factors that hold the chromosomes together.
Keywords: Aneuploidy; cell cycle; chromosomes; meiosis; oocyte
Rights: © 2013. Published by The Company of Biologists Ltd
DOI: 10.1242/dev.090589
Grant ID: ARC
Published version:
Appears in Collections:Aurora harvest 8
Molecular and Biomedical Science publications

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