Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Development (Cambridge), 2013; 140(18):3719-3730||-|
|dc.description.abstract||Mammalian oocytes are particularly error prone in segregating their chromosomes during their two meiotic divisions. This results in the creation of an embryo that has inherited the wrong number of chromosomes: it is aneuploid. The incidence of aneuploidy rises significantly with maternal age and so there is much interest in understanding this association and the underlying causes of aneuploidy. The spindle assembly checkpoint, a surveillance mechanism that operates in all cells to prevent chromosome mis-segregation, and the cohesive ties that hold those chromosomes together, have thus both been the subject of intensive investigation in oocytes. It is possible that a lowered sensitivity of the spindle assembly checkpoint to certain types of chromosome attachment error may endow oocytes with an innate susceptibility to aneuploidy, which is made worse by an age-related loss in the factors that hold the chromosomes together.||-|
|dc.description.statementofresponsibility||Keith T. Jones and Simon I. R. Lane||-|
|dc.publisher||The Company of Biologists Ltd||-|
|dc.rights||© 2013. Published by The Company of Biologists Ltd||-|
|dc.subject||Aneuploidy; cell cycle; chromosomes; meiosis; oocyte||-|
|dc.title||Molecular causes of aneuploidy in mammalian eggs||-|
|dc.identifier.orcid||Jones, K.T. [0000-0002-0294-0851]||-|
|Appears in Collections:||Aurora harvest 8|
Molecular and Biomedical Science publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.