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Type: Journal article
Title: Nanoformulated antimicrobial agents for central nervous system infections
Author: Zhang, S.
Chen, Y.
Liang, J.
Wang, S.
Liu, L.
Liu, S.
Citation: Journal of Nanoscience and Nanotechnology, 2017; 17(12):8683-8698
Publisher: American Scientific Publishers
Issue Date: 2017
ISSN: 1533-4880
Statement of
Shaokun Zhang, Yan Chen, Junli Liang, Shaobin Wang, Lihong Liu, Shaomin Liu
Abstract: Meningitis and encephalitis caused by bacteria and fungi are among the top 10 lethal types of infectious diseases. The treatment of brain infection is principally limited by the blood-brain barrier (BBB), which restricts the entry of antimicrobial agents to the desired central nervous system (CNS). To address this issue, many different nanoparticles conjugated with targeting ligands have been employed to increase CNS penetration of several antifungal drugs like amphotericin B and itraconazole. However, a wide spectrum of microorganisms have provoked the diseases, and some have developed multidrug resistance to nearly all commercially available antibiotics. Therefore, there is an urgent need to design unconventional nanostructures that possess both novel biocidal modes and brain targeting property. This review focuses on classical nanocarriers enabling brain delivery of loaded antibiotics as well as highlights recent progress in the fabrication of transactivator of transcription (TAT) peptide-containing nanoparticles to circumvent BBB and kill the pathogenic microbes in brain tissue. The later strategy, albeit imperfect, may allow nanoantibiotics to target, diagnose and treat brain infection simultaneously in an unprecedented manner.
Keywords: Antibiotics; blood-brain barrier; drug delivery; liposomes; micelles; nanoparticles
Rights: Copyright Status Unknown
DOI: 10.1166/jnn.2017.14693
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Appears in Collections:Aurora harvest 3
Chemical Engineering publications

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