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Type: Journal article
Title: New opportunities for targeting the androgen receptor in prostate cancer
Author: Centenera, M.
Selth, L.
Ebrahimie, E.
Butler, L.
Tilley, W.
Citation: Cold Spring Harbor Perspectives in Medicine, 2018; 10(12):1-19
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2018
ISSN: 2157-1422
Statement of
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler and Wayne D. Tilley
Abstract: Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.
Keywords: Humans
Prostatic Neoplasms
Androgen Antagonists
Molecular Chaperones
Protein Isoforms
Receptors, Androgen
Antineoplastic Agents, Hormonal
Antineoplastic Combined Chemotherapy Protocols
Gene Amplification
Drug Resistance, Neoplasm
Molecular Targeted Therapy
Prostatic Neoplasms, Castration-Resistant
Rights: Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved
DOI: 10.1101/cshperspect.a030478
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