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Type: Journal article
Title: New opportunities for targeting the androgen receptor in prostate cancer
Author: Centenera, M.
Selth, L.
Ebrahimie, E.
Butler, L.
Tilley, W.
Citation: Cold Spring Harbor Perspectives in Medicine, 2018; 10(12):1-19
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2018
ISSN: 2157-1422
Statement of
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler and Wayne D. Tilley
Abstract: Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.
Keywords: Humans; Prostatic Neoplasms; Phenylthiohydantoin; Androstenes; Androgen Antagonists; Molecular Chaperones; Protein Isoforms; Receptors, Androgen; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Gene Amplification; Drug Resistance, Neoplasm; Mutation; Male; Molecular Targeted Therapy; Prostatic Neoplasms, Castration-Resistant
Rights: Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved
RMID: 0030083663
DOI: 10.1101/cshperspect.a030478
Grant ID:
Appears in Collections:Medicine publications

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